Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 17/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | INSR | P06213 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 2/20 | 0.37 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL400353 | 0.84 | IGF1R (0.61) | IGF1RCYP3A4EGFRINSRKDR | |
| SCHEMBL5139332 | 0.82 | IGF1R (0.57) | IGF1RCYP3A4EGFRINSRKDR | |
| SCHEMBL5082145 | 0.80 | IGF1R (0.39) | IGF1RCYP3A4EGFRINSRKDR | |
| SCHEMBL5081943 | 0.79 | IGF1R (0.35) | IGF1RCYP3A4KIT | |
| SCHEMBL5313007 | 0.76 | IGF1R (0.45) | IGF1RCYP3A4BTK | |
| SCHEMBL5139317 | 0.75 | IGF1R (0.51) | IGF1RCYP3A4EGFRINSRKDR | |
| SCHEMBL400937 | 0.74 | IGF1R (0.71) | IGF1RCYP3A4EGFRINSRKDR | |
| SCHEMBL19264006 | 0.73 | IGF1R (0.54) | IGF1RCYP3A4EGFRINSRKDR | |
| SCHEMBL3909073 | 0.73 | IGF1R (0.55) | IGF1RCYP3A4EGFRINSRKDR | |
| SCHEMBL19264009 | 0.72 | IGF1R (0.53) | IGF1RCYP3A4EGFRINSRKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008076143-A1 | COMBINATION OF IGFR INHIBITOR AND ANTI-CANCER AGENT | OSI PHARMACEUTICALS, INC. (US) | 2008-06-26 | — | — | WO | disclosed |