Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | BTK | Q06187 | 9/20 | 0.44 |
| ▸ | TNK2 | Q07912 | 10/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5139317 | 0.88 | IGF1R (0.51) | IGF1RCYP3A4BTKTNK2 | |
| SCHEMBL400491 | 0.83 | IGF1R (0.66) | IGF1RCYP3A4TNK2 | |
| SCHEMBL5139332 | 0.79 | IGF1R (0.57) | IGF1RCYP3A4TNK2 | |
| Carbamic Acid SCHEMBL4060715 | 0.78 | IGF1R (0.61) | IGF1RCYP3A4TNK2 | |
| SCHEMBL5083975 | 0.76 | IGF1R (0.43) | IGF1RCYP3A4BTK | |
| SCHEMBL5086159 | 0.76 | TNK2 (0.35) | IGF1RCYP3A4TNK2 | |
| SCHEMBL10225365 | 0.75 | IGF1R (0.64) | IGF1RCYP3A4TNK2 | |
| SCHEMBL400649 | 0.75 | IGF1R (0.69) | IGF1RCYP3A4BTKTNK2 | |
| SCHEMBL5082381 | 0.75 | IGF1R (0.47) | IGF1RCYP3A4BTKTNK2 | |
| SCHEMBL399410 | 0.74 | IGF1R (0.70) | IGF1RCYP3A4TNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740591-A1 | 6,6-BICYCLIC RING SUBSTITUTED HETEROBICYCLIC PROTEIN KINASE INHIBITORS | OSI Pharmaceuticals, Inc. (US) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005097800-A1 | 6,6-BICYCLIC RING SUBSTITUTED HETEROBICYCLIC PROTEIN KINASE INHIBITORS | OSI PHARMACEUTICALS, INC. (US) | 2005-10-20 | — | — | WO | disclosed |