Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 1/20 | 0.80 |
| ▸ | NPC1 | O15118 | 4/20 | 0.77 |
| ▸ | RAB9A | P51151 | 4/20 | 0.77 |
| ▸ | AR | P10275 | 3/20 | 0.72 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.70 |
| ▸ | LMNA | P02545 | 4/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.65 |
| ▸ | POLB | P06746 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | TP53 | P04637 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14303260 | 0.98 | BCHE (0.83) | BCHENPC1RAB9AAREPHX2 | |
| SCHEMBL14304387 | 0.98 | BCHE (0.83) | BCHENPC1RAB9AAREPHX2 | |
| SCHEMBL14304381 | 0.98 | BCHE (0.83) | BCHENPC1RAB9AAREPHX2 | |
| SCHEMBL6141660 | 0.98 | BCHE (0.83) | BCHENPC1RAB9AAREPHX2 | |
| SCHEMBL14303261 | 0.98 | BCHE (0.83) | BCHENPC1RAB9AAREPHX2 | |
| SCHEMBL14304932 | 0.96 | BCHE (0.86) | BCHENPC1RAB9AAREPHX2 | |
| SCHEMBL6608285 | 0.92 | EPHX2 (0.79) | BCHENPC1RAB9AAREPHX2 | |
| SCHEMBL6605155 | 0.92 | EPHX2 (0.79) | BCHENPC1RAB9AAREPHX2 | |
| SCHEMBL6604271 | 0.92 | EPHX2 (0.79) | BCHENPC1RAB9AAREPHX2 | |
| SCHEMBL11535096 | 0.91 | NPC1 (0.88) | BCHENPC1RAB9AAREPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7358313-B2 | Thiouronium salt as anti-reversion agent in a vulcanizable rubber composition and tire based on such a composition | MICHELIN RECHERCHE ET TECHNIQUE S.A. (CH) | 2008-04-15 | — | — | US | disclosed |
| US-20050187340-A1 | Thiouronium salt as anti-reversion agent in a vulcanizable rubber composition and tire based on such a composition | MICHELIN RECHERCHE ET TECHNIQUE S.A. (CH) | 2005-08-25 | — | — | US | disclosed |