Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.71 |
| ▸ | ARG2 | P78540 | 4/20 | 0.46 |
| ▸ | ARG1 | P05089 | 3/20 | 0.46 |
| ▸ | NOS2 | P35228 | 5/20 | 0.45 |
| ▸ | NOS1 | P29475 | 4/20 | 0.45 |
| ▸ | NOS3 | P29474 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL21816467 | 1.00 | GSR (0.71) | GSRARG2ARG1NOS2NOS1 | |
| Lysine SCHEMBL746846 | 1.00 | GSR (0.71) | GSRARG2ARG1NOS2NOS1 | |
| Lysine SCHEMBL1537434 | 1.00 | GSR (0.71) | GSRARG2ARG1NOS2NOS1 | |
| Lysine SCHEMBL3358270 | 1.00 | GSR (0.71) | GSRARG2ARG1NOS2NOS1 | |
| Lysine SCHEMBL1537438 | 1.00 | GSR (0.71) | GSRARG2ARG1NOS2NOS1 | |
| Lysine SCHEMBL746845 | 1.00 | GSR (0.71) | GSRARG2ARG1NOS2NOS1 | |
| Lysine SCHEMBL6130146 | 0.97 | GSR (0.67) | GSRARG2ARG1NOS2NOS1 | |
| Lysine SCHEMBL23292473 | 0.95 | GSR (0.65) | GSRARG2ARG1NOS2NOS1 | |
| Lysine SCHEMBL15674546 | 0.95 | GSR (0.65) | GSRARG2ARG1NOS2NOS1 | |
| Lysine SCHEMBL8322630 | 0.95 | GSR (0.65) | GSRARG2ARG1NOS2NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080003236-A1 | ADENOVIRUS FIBER SHAFT COMPOSITION AND METHODS OF USE | GENVEC, INC. (US) | 2008-01-03 | — | — | US | claimed |
| EP-1802762-A2 | ADENOVIRUS FIBER SHAFT COMPOSITION AND METHODS OF USE | GENVEC, INC. (US) | 2007-07-04 | — | — | EP | claimed |
| WO-2006044736-A2 | ADENOVIRUS FIBER SHAFT COMPOSITION AND METHODS OF USE | GENVEC, INC. (US) | 2006-04-27 | — | — | WO | claimed |
| US-20080003236-A1 | ADENOVIRUS FIBER SHAFT COMPOSITION AND METHODS OF USE | GENVEC, INC. (US) | 2008-01-03 | — | — | US | disclosed |
| EP-1802762-A2 | ADENOVIRUS FIBER SHAFT COMPOSITION AND METHODS OF USE | GENVEC, INC. (US) | 2007-07-04 | — | — | EP | disclosed |
| WO-2006044736-A2 | ADENOVIRUS FIBER SHAFT COMPOSITION AND METHODS OF USE | GENVEC, INC. (US) | 2006-04-27 | — | — | WO | disclosed |