Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.71 |
| ▸ | ARG2 | P78540 | 4/20 | 0.46 |
| ▸ | ARG1 | P05089 | 3/20 | 0.46 |
| ▸ | NOS2 | P35228 | 5/20 | 0.45 |
| ▸ | NOS1 | P29475 | 4/20 | 0.45 |
| ▸ | NOS3 | P29474 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL5084119 | 1.00 | GSR (0.71) | GSRARG2ARG1NOS2NOS1 | |
| Lysine SCHEMBL21816467 | 1.00 | GSR (0.71) | GSRARG2ARG1NOS2NOS1 | |
| Lysine SCHEMBL746846 | 1.00 | GSR (0.71) | GSRARG2ARG1NOS2NOS1 | |
| Lysine SCHEMBL1537434 | 1.00 | GSR (0.71) | GSRARG2ARG1NOS2NOS1 | |
| Lysine SCHEMBL3358270 | 1.00 | GSR (0.71) | GSRARG2ARG1NOS2NOS1 | |
| Lysine SCHEMBL1537438 | 1.00 | GSR (0.71) | GSRARG2ARG1NOS2NOS1 | |
| Lysine SCHEMBL6130146 | 0.97 | GSR (0.67) | GSRARG2ARG1NOS2NOS1 | |
| Lysine SCHEMBL23292473 | 0.95 | GSR (0.65) | GSRARG2ARG1NOS2NOS1 | |
| Lysine SCHEMBL15674546 | 0.95 | GSR (0.65) | GSRARG2ARG1NOS2NOS1 | |
| Lysine SCHEMBL8322630 | 0.95 | GSR (0.65) | GSRARG2ARG1NOS2NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 101 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9421190-B2 | Compositions comprising amino acids for prevention and/or treatment of renal disorders | DETERMINANTS OF METABOLISM RESEARCH LABORATORY S.R.L. (IT) | 2016-08-23 | — | — | US | claimed |
| US-5736142-A | GENETIC ENGINEERING | CYTEL CORPORATION (US) | 1998-04-07 | — | — | US | claimed |
| CN-117625547-B | New generation chimeric antigen receptor for combined expression of GPX4 and application thereof | 广州百吉生物制药有限公司 | 2024-06-28 | — | — | CN | disclosed |
| CN-118001339-A | Preparation method of black sesame pill for strengthening spleen and aiding sleep | 壹品荟(河南)实业发展有限公司 | 2024-05-10 | — | — | CN | disclosed |
| CN-117625547-A | New generation chimeric antigen receptor for combined expression of GPX4 and application thereof | 广州百吉生物制药有限公司 | 2024-03-01 | — | — | CN | disclosed |
| CN-115477704-B | Preparation and application of chimeric antigen receptor immune cells constructed based on LOX1 | 四川大学华西医院 | 2024-02-23 | — | — | CN | disclosed |
| CN-115477705-B | Preparation and application of chimeric antigen receptor immune cells constructed based on granzyme B | 四川大学华西医院 | 2024-02-23 | — | — | CN | disclosed |
| CN-115806626-B | Preparation and application of chimeric antigen receptor immune cells based on CSF1 | 四川大学华西医院 | 2024-02-23 | — | — | CN | disclosed |
| CN-115819614-B | Preparation and application of chimeric antigen receptor immune cells based on IL34 | 四川大学华西医院 | 2024-02-23 | — | — | CN | disclosed |
| CN-117561281-A | Methods and compositions for treating tumors | 科济生物医药（上海）有限公司 | 2024-02-13 | — | — | CN | disclosed |
| CN-117545771-A | Application of cellular immunotherapy | 克莱格医学有限公司 | 2024-02-09 | — | — | CN | disclosed |
| WO-2008101850-A1 | METHOD OF PRODUCING METHIONINE IN CORYNEBACTERIA BY OVER-EXPRESSING ENZYMES OF THE PENTOSE PHOSPHATE PATHWAY | EVONIK DEGUSSA GMBH (DE) | 2008-08-28 | — | — | WO | disclosed |
| CN-1165614-C | animal feed additive containing xylanase | ŵ����÷������˾ | 2004-09-08 | — | — | CN | disclosed |
| US-20030100113-A1 | Non-viral transfection vector | UNIVERSITE LOUIS PASTEUR DE STRASBOURG (FR) | 2003-05-29 | — | — | US | disclosed |
| US-6514697-B1 | Biological and environmental samples using GP900, P68 or cryptopain antigens/antibodies or DNA/RNA;Immunoassay | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2003-02-04 | — | — | US | disclosed |
| WO-2001094631-A1 | METHODS FOR DETECTION OF CRYPTOSPORIDIUM SPECIES AND ISOLATES AND FOR DIAGNOSIS OF CRYPTOSPORIDIUMINFECTIONS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2001-12-13 | — | — | WO | disclosed |
| EP-1013770-A1 | Non-viral transfection vector | Université Louis Pasteur de Strasbourg (FR) | 2000-06-28 | — | — | EP | disclosed |
| US-6071518-A | GENETIC ENGINEERING | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2000-06-06 | — | — | US | disclosed |
| WO-1999058640-A2 | MCT-1, A HUMAN ONCOGENE | PHILADELPHIA HEALTH AND EDUCATION CORPORATION (US) | 1999-11-18 | — | — | WO | disclosed |
| CN-1169752-A | animal feed additive containing xylanase | NOVO NORDISK AS (DK) | 1998-01-07 | — | — | CN | disclosed |