SCHEMBL5084370

SCHEMBL5084370

COc1cc(C2CC(=O)c3c(O)cc(O)cc3O2)cc(OC)c1OC

nearest known ligand 0.77

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A1 P04798 5/20 0.77
CYP1A2 P05177 5/20 0.77
CYP1B1 Q16678 5/20 0.77
POLB P06746 1/20 0.77
CYP3A4 P08684 5/20 0.73
CYP19A1 P11511 5/20 0.73
MAPT P10636 3/20 0.73
CYP2C9 P11712 3/20 0.73
CYP2C19 P33261 3/20 0.73
HSD17B10 Q99714 3/20 0.73
TP53 P04637 2/20 0.73
XDH P47989 2/20 0.73
ATM Q13315 2/20 0.73
CA12 O43570 2/20 0.73
CA4 P22748 2/20 0.73
DPP4 P27487 2/20 0.73
CA7 P43166 2/20 0.73
GSK3B P49841 2/20 0.73
CYP2D6 P10635 2/20 0.73
HPGD P15428 1/20 0.73

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7196754 0.91 CYP1A1 (0.78) CYP1A1CYP1A2CYP1B1POLBCYP3A4
SCHEMBL31028356 0.87 CYP19A1 (0.87) CYP1A1CYP1A2CYP1B1POLBCYP3A4
Homoeriodictyol SCHEMBL30016824 0.87 CYP1A1 (1.00) CYP1A1CYP1A2CYP1B1POLBCYP3A4
Homoeriodictyol SCHEMBL2307702 0.87 CYP1A1 (1.00) CYP1A1CYP1A2CYP1B1POLBCYP3A4
Homoeriodictyol SCHEMBL39497 0.87 CYP1A1 (1.00) CYP1A1CYP1A2CYP1B1POLBCYP3A4
Homoeriodictyol SCHEMBL30383489 0.87 CYP1A1 (1.00) CYP1A1CYP1A2CYP1B1POLBCYP3A4
Homoeriodictyol SCHEMBL29411740 0.87 CYP1A1 (1.00) CYP1A1CYP1A2CYP1B1POLBCYP3A4
SCHEMBL25221390 0.87 PTPN1 (0.89) CYP1A1CYP1A2CYP1B1POLBCYP19A1
Homoeriodictyol SCHEMBL2019518 0.86 CYP1A1 (0.98) CYP1A1CYP1A2CYP1B1POLBCYP3A4
Homoeriodictyol SCHEMBL2024548 0.86 CYP1A1 (0.98) CYP1A1CYP1A2CYP1B1POLBCYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4483866-A1 PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OR PREVENTION OF CANCER Makrolife Biotech GmbH (DE) 2025-01-01 EP claimed
EP-4483866-A1 PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OR PREVENTION OF CANCER Makrolife Biotech GmbH (DE) 2025-01-01 EP disclosed
CN-109890378-A FOXO1 activity-inhibiting composition 三得利控股株式会社 2019-06-14 CN disclosed
US-20170071902-A1 NOX INHIBITOR AND NFkB INHIBITOR CONTAINING METHOXYFLAVONE SUNTORY HOLDINGS LIMITED (JP) 2017-03-16 US disclosed
WO-2007115181-A9 COMPOUNDS EXHIBITING EFFLUX INHIBITOR ACTIVITY AND COMPOSITIONS AND USES THEREOF EASTMAN CHEM CO (US) 2008-04-03 WO disclosed
US-20070254859-A1 Compounds exhibiting efflux inhibitor activity and composition and uses thereof EASTMAN CHEMICAL COMPANY 2007-11-01 US disclosed
WO-2007115181-A2 COMPOUNDS EXHIBITING EFFLUX INHIBITOR ACTIVITY AND COMPOSITIONS AND USES THEREOF EASTMAN CHEMICAL COMPANY (US) 2007-10-11 WO disclosed
WO-2003057210-A1 COMPOSITIONS AND METHODS FOR INCREASING CELL PROLIFERATION COMPRISING A FLAVONOID KIMBERLY-CLARK WORLDWIDE, INC. (US) 2003-07-17 WO disclosed
US-20030125264-A1 Methods For Treating Wounds KIMBERLY-CLARK WORLDWIDE, INC. 2003-07-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070254859-A1 Compounds exhibiting efflux inhibitor activity and composition and uses thereof ABCC4, NCOA4, NR4A3 CYP1A1 215/4885CYP1A2 319/4885CYP1B1 316/4885
US-20170071902-A1 NOX INHIBITOR AND NFkB INHIBITOR CONTAINING METHOXYFLAVONE NOX1, NFKBIA, NOX5 CYP1A1 602/4885CYP1A2 1169/4885CYP1B1 412/4885
US-20030125264-A1 Methods For Treating Wounds FGF2, MMP1, FIBP CYP1A1 1856/4885CYP1A2 1713/4885CYP1B1 1640/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.