Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.69 |
| ▸ | POLB | P06746 | 7/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.66 |
| ▸ | USP2 | O75604 | 1/20 | 0.63 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.63 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.63 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.63 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.63 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | THRB | P10828 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL379054 | 0.87 | ALDH1A1 (0.67) | AKR1B1POLBKMT2AALDH1A1KDM4E | |
| SCHEMBL13910970 | 0.87 | POLB (0.64) | AKR1B1POLBKMT2AALDH1A1KDM4E | |
| SCHEMBL8106900 | 0.87 | POLB (0.62) | AKR1B1POLBKMT2AALDH1A1KDM4E | |
| SCHEMBL5275063 | 0.81 | AKR1B1 (1.00) | AKR1B1KMT2AALDH1A1KDM4EUSP2 | |
| SCHEMBL4248840 | 0.81 | AKR1B1 (0.71) | AKR1B1POLBKMT2AALDH1A1KDM4E | |
| SCHEMBL8117451 | 0.80 | AKR1B1 (0.78) | AKR1B1POLBKMT2AKDM4EMAPT | |
| SCHEMBL6331139 | 0.80 | ALDH1A1 (0.77) | AKR1B1POLBKMT2AALDH1A1KDM4E | |
| SCHEMBL29495395 | 0.80 | AKR1B1 (0.69) | AKR1B1POLBKMT2AALDH1A1KDM4E | |
| SCHEMBL18397901 | 0.80 | AKR1B1 (0.69) | AKR1B1POLBKMT2AALDH1A1KDM4E | |
| SCHEMBL10649648 | 0.80 | AKR1B1 (0.69) | AKR1B1POLBKMT2AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007115181-A9 | COMPOUNDS EXHIBITING EFFLUX INHIBITOR ACTIVITY AND COMPOSITIONS AND USES THEREOF | EASTMAN CHEM CO (US) | 2008-04-03 | — | — | WO | claimed |
| WO-2007115181-A2 | COMPOUNDS EXHIBITING EFFLUX INHIBITOR ACTIVITY AND COMPOSITIONS AND USES THEREOF | EASTMAN CHEMICAL COMPANY (US) | 2007-10-11 | — | — | WO | claimed |
| CN-116964044-A | Acetamido-phenyltetrazole derivatives and methods of use thereof | 希华医药有限公司 | 2023-10-27 | — | — | CN | disclosed |
| CN-116940562-A | Acetamido-phenylbenzamide derivatives and methods of use thereof | 希华医药有限公司 | 2023-10-24 | — | — | CN | disclosed |
| CN-114401952-A | Substituted cycloalkyl compounds as modulators of integrated stress pathways | 卡里科生命科学有限责任公司 | 2022-04-26 | — | — | CN | disclosed |
| EP-3962899-A1 | SUBSTITUTED CYCLOLAKYLS AS MODULATORS OF THE INTEGRATED STRESS PATHWAY | Calico Life Sciences LLC (US) | 2022-03-09 | — | — | EP | disclosed |
| WO-2020223536-A1 | SUBSTITUTED CYCLOLAKYLS AS MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2020-11-05 | — | — | WO | disclosed |
| CN-104327030-A | Simple synthetic method of 4-chromone derivative | UNIV YUNNAN NATIONALITIES | 2015-02-04 | — | — | CN | disclosed |