Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.77 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.75 |
| ▸ | POLB | P06746 | 1/20 | 0.66 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.66 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.66 |
| ▸ | MAOB | P27338 | 3/20 | 0.65 |
| ▸ | NPC1 | O15118 | 2/20 | 0.65 |
| ▸ | MAPT | P10636 | 2/20 | 0.65 |
| ▸ | RAB9A | P51151 | 2/20 | 0.65 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | AR | P10275 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5084433 | 1.00 | PTPN1 (0.77) | PTPN1CYP19A1POLBCYP1A1CYP1A2 | |
| SCHEMBL27183317 | 0.90 | CYP19A1 (0.75) | PTPN1CYP19A1CYP1A1CYP1A2CYP1B1 | |
| Homoeriodictyol SCHEMBL19127668 | 0.89 | CYP1A1 (0.81) | PTPN1CYP19A1POLBCYP1A1CYP1A2 | |
| SCHEMBL2966440 | 0.87 | PTPN1 (1.00) | PTPN1CYP19A1POLBCYP1A1CYP1A2 | |
| SCHEMBL29684675 | 0.87 | PTPN1 (1.00) | PTPN1CYP19A1POLBCYP1A1CYP1A2 | |
| SCHEMBL31028359 | 0.87 | PTPN1 (1.00) | PTPN1CYP19A1POLBCYP1A1CYP1A2 | |
| SCHEMBL14003755 | 0.86 | PTPN1 (0.60) | PTPN1CYP19A1POLBCYP1A1CYP1A2 | |
| SCHEMBL14177145 | 0.86 | PTPN1 (0.70) | PTPN1CYP19A1POLBCYP1A1CYP1A2 | |
| SCHEMBL6575796 | 0.84 | CYP19A1 (0.73) | CYP19A1POLBCYP1A1CYP1A2CYP1B1 | |
| SCHEMBL6575800 | 0.84 | CYP19A1 (0.73) | CYP19A1POLBCYP1A1CYP1A2CYP1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007115181-A9 | COMPOUNDS EXHIBITING EFFLUX INHIBITOR ACTIVITY AND COMPOSITIONS AND USES THEREOF | EASTMAN CHEM CO (US) | 2008-04-03 | — | — | WO | disclosed |
| US-20070254859-A1 | Compounds exhibiting efflux inhibitor activity and composition and uses thereof | EASTMAN CHEMICAL COMPANY | 2007-11-01 | — | — | US | disclosed |
| WO-2007115181-A2 | COMPOUNDS EXHIBITING EFFLUX INHIBITOR ACTIVITY AND COMPOSITIONS AND USES THEREOF | EASTMAN CHEMICAL COMPANY (US) | 2007-10-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070254859-A1 | Compounds exhibiting efflux inhibitor activity and composition and uses thereof | ABCC4, NCOA4, NR4A3 | PTPN1 630/4885CYP19A1 214/4885POLB 3941/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.