Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.50 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.50 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KIF11 | P52732 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 3/20 | 0.41 |
| ▸ | MAOB | P27338 | 3/20 | 0.41 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.39 |
| ▸ | FDPS | P14324 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21879997 | 0.97 | TAAR1 (0.52) | TAAR1SLC6A2LOXL2SMN1; SMN2HIF1A | |
| Hydrochloric Acid SCHEMBL5091679 | 0.95 | TAAR1 (0.50) | TAAR1SLC6A2LOXL2SMN1; SMN2HIF1A | |
| Iodide SCHEMBL5087566 | 0.95 | TAAR1 (0.50) | TAAR1SLC6A2LOXL2SMN1; SMN2HIF1A | |
| SCHEMBL9746335 | 0.92 | TAAR1 (0.52) | TAAR1SLC6A2LOXL2SMN1; SMN2HIF1A | |
| Bromide SCHEMBL5091825 | 0.81 | TAAR1 (0.46) | TAAR1SLC6A2LOXL2SMN1; SMN2HIF1A | |
| SCHEMBL11843995 | 0.81 | SLC6A2 (0.55) | TAAR1SLC6A2LOXL2SMN1; SMN2HIF1A | |
| Bromide SCHEMBL10680852 | 0.78 | TAAR1 (0.48) | TAAR1SLC6A2LOXL2SMN1; SMN2HIF1A | |
| Bromide SCHEMBL5085118 | 0.78 | KIF11 (0.50) | TAAR1SLC6A2LOXL2SMN1; SMN2HIF1A | |
| Iodide SCHEMBL5092958 | 0.76 | TAAR1 (0.46) | TAAR1SLC6A2LOXL2SMN1; SMN2HIF1A | |
| Hydrochloric Acid SCHEMBL5085043 | 0.76 | TAAR1 (0.46) | TAAR1SLC6A2LOXL2SMN1; SMN2HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080214386-A1 | Stability; easily separated from solution; surface treatment of catalyst with Group seven compound; reacting epoxide with carbon dioxide | NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY (JP) | 2008-09-04 | — | — | US | disclosed |