Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 9/20 | 0.39 |
| ▸ | PPARG | P37231 | 6/20 | 0.39 |
| ▸ | PPARD | Q03181 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | MIF | P14174 | 1/20 | 0.35 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.35 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.35 |
| ▸ | ORAI3 | Q9BRQ5 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | POLQ | O75417 | 1/20 | 0.34 |
| ▸ | ESRRG | P62508 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 2/20 | 0.34 |
| ▸ | CA1 | P00915 | 2/20 | 0.34 |
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
| ▸ | CA7 | P43166 | 2/20 | 0.34 |
| ▸ | CA9 | Q16790 | 2/20 | 0.34 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5017451 | 1.00 | EPHX2 (0.39) | EPHX2PPARGPPARDPPARAESR1 | |
| SCHEMBL3374300 | 0.83 | CHRNA7 (0.38) | PPARAESR1ESR2MIFALOX5 | |
| SCHEMBL3372979 | 0.83 | ESR1 (0.39) | PPARGPPARAESR1ESR2MIF | |
| SCHEMBL3402960 | 0.83 | ESR1 (0.39) | PPARGPPARAESR1ESR2MIF | |
| SCHEMBL3371001 | 0.82 | NR3C1 (0.43) | ESR1ESR2MIFCA12CA1 | |
| SCHEMBL5017407 | 0.82 | NR3C1 (0.43) | ESR1ESR2MIFCA12CA1 | |
| SCHEMBL5022444 | 0.81 | PPARG (0.49) | EPHX2PPARGPPARDPPARA | |
| SCHEMBL5095387 | 0.81 | APP (0.42) | ESR1ESR2MIFALOX5CA12 | |
| SCHEMBL3370534 | 0.81 | CYP3A4 (0.39) | PPARGPPARAESR1ESR2MIF | |
| SCHEMBL3372793 | 0.81 | APP (0.42) | ESR1ESR2MIFALOX5CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551814-B1 | CHIRALE OXAZOLE-ARYLPROPIONIC ACID DERIVATIVES AND THEIR USE AS PPAR AGONISTS | HOFFMANN LA ROCHE (CH) | 2008-07-23 | — | — | EP | disclosed |