Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALM1 | P0DP23 | 1/20 | 0.42 |
| ▸ | BCL2 | P10415 | 1/20 | 0.41 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | CTRC | Q99895 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4627893 | 0.98 | CALM1 (0.44) | CALM1BCL2BCL2L1ALOX5HTR2A | |
| Iodide SCHEMBL5086774 | 0.96 | CALM1 (0.42) | CALM1BCL2BCL2L1ALOX5HTR2A | |
| Hydrochloric Acid SCHEMBL5091607 | 0.96 | CALM1 (0.42) | CALM1BCL2BCL2L1ALOX5HTR2A | |
| SCHEMBL1046166 | 0.85 | CALM1 (0.58) | CALM1BCL2BCL2L1ALOX5HTR2A | |
| SCHEMBL4250559 | 0.82 | CALM1 (0.44) | CALM1BCL2BCL2L1ALOX5HTR2A | |
| Bromide SCHEMBL5088657 | 0.76 | HTR2A (0.42) | CALM1BCL2BCL2L1ALOX5HTR2A | |
| SCHEMBL5576274 | 0.75 | CALM1 (0.46) | CALM1BCL2BCL2L1ALOX5HTR2A | |
| SCHEMBL11843990 | 0.75 | TP53 (0.48) | CALM1BCL2BCL2L1ALOX5HTR2A | |
| SCHEMBL31167415 | 0.75 | TP53 (0.48) | CALM1BCL2BCL2L1ALOX5HTR2A | |
| SCHEMBL1704793 | 0.73 | CALM1 (0.44) | CALM1BCL2BCL2L1ALOX5HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080214386-A1 | Stability; easily separated from solution; surface treatment of catalyst with Group seven compound; reacting epoxide with carbon dioxide | NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY (JP) | 2008-09-04 | — | — | US | disclosed |