Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 14/20 | 0.73 |
| ▸ | SLC6A4 | P31645 | 13/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTR1E | P28566 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3516343 | 1.00 | SLC6A3 (0.73) | SLC6A3SLC6A4SLC6A2CYP2D6EPHX1 | |
| SCHEMBL3520440 | 1.00 | SLC6A3 (0.73) | SLC6A3SLC6A4SLC6A2CYP2D6EPHX1 | |
| SCHEMBL3516344 | 1.00 | SLC6A3 (0.73) | SLC6A3SLC6A4SLC6A2CYP2D6EPHX1 | |
| SCHEMBL3520438 | 1.00 | SLC6A3 (0.73) | SLC6A3SLC6A4SLC6A2CYP2D6EPHX1 | |
| SCHEMBL3516341 | 1.00 | SLC6A3 (0.73) | SLC6A3SLC6A4SLC6A2CYP2D6EPHX1 | |
| SCHEMBL3516124 | 0.84 | SLC6A3 (1.00) | SLC6A3SLC6A4SLC6A2CYP2D6HDAC1 | |
| SCHEMBL3516127 | 0.84 | SLC6A3 (1.00) | SLC6A3SLC6A4SLC6A2CYP2D6HDAC1 | |
| SCHEMBL3520237 | 0.84 | SLC6A3 (1.00) | SLC6A3SLC6A4SLC6A2CYP2D6HDAC1 | |
| SCHEMBL3516126 | 0.84 | SLC6A3 (1.00) | SLC6A3SLC6A4SLC6A2CYP2D6HDAC1 | |
| SCHEMBL3520235 | 0.84 | SLC6A3 (1.00) | SLC6A3SLC6A4SLC6A2CYP2D6HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1976513-A2 | CYCLOALKYLAMINES AS MONOAMINE REUPTAKE INHIBITORS | Sepracor, Inc. (US) | 2008-10-08 | — | — | EP | disclosed |
| WO-2007081857-A2 | CYCLOALKYLAMINES AS MONOAMINE REUPTAKE INHIBITORS | SEPRACOR INC. (US) | 2007-07-19 | — | — | WO | disclosed |