Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | FAAH | O00519 | 3/20 | 0.48 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CTSA | P10619 | 4/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL844472 | 0.89 | SMN1; SMN2 (0.57) | SMN1; SMN2MAPK1FAAHNPC1RAB9A | |
| SCHEMBL14040614 | 0.89 | SMN1; SMN2 (0.57) | SMN1; SMN2MAPK1FAAHNPC1RAB9A | |
| SCHEMBL4097623 | 0.88 | SMN1; SMN2 (0.48) | SMN1; SMN2MAPK1FAAHNPC1RAB9A | |
| SCHEMBL3663293 | 0.88 | FAAH (0.58) | SMN1; SMN2MAPK1FAAHNPC1RAB9A | |
| SCHEMBL16680706 | 0.88 | SMN1; SMN2 (0.48) | SMN1; SMN2MAPK1FAAHNPC1RAB9A | |
| SCHEMBL4265545 | 0.88 | SMN1; SMN2 (0.50) | SMN1; SMN2MAPK1FAAHNPC1RAB9A | |
| SCHEMBL2320404 | 0.88 | FAAH (0.59) | SMN1; SMN2MAPK1FAAHCYP26A1NPC1 | |
| SCHEMBL5181827 | 0.88 | KMT2A (0.53) | SMN1; SMN2MAPK1FAAHCYP26A1NPC1 | |
| SCHEMBL2367175 | 0.86 | SMN1; SMN2 (0.57) | SMN1; SMN2MAPK1FAAHNPC1RAB9A | |
| SCHEMBL5504818 | 0.86 | SMN1; SMN2 (0.57) | SMN1; SMN2MAPK1FAAHNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008101840-A1 | COMBINATION OF ERLOTINIB AND MEK-INHIBITORS FOR INHIBITING PROLIFERATION OF TUMOR CELLS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-08-28 | — | — | WO | disclosed |