Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.54 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.54 |
| ▸ | ELANE | P08246 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11104124 | 0.85 | LMNA (0.50) | LMNASMN1; SMN2POLBHTTNCOA1 | |
| SCHEMBL28732550 | 0.78 | LMNA (0.49) | LMNASMN1; SMN2POLBHTTNCOA1 | |
| SCHEMBL9593290 | 0.78 | LMNA (0.62) | LMNASMN1; SMN2ELANEMAPTKDM4E | |
| SCHEMBL9724222 | 0.77 | LMNA (0.56) | LMNASMN1; SMN2ELANEMAPTKDM4E | |
| SCHEMBL28732557 | 0.77 | LMNA (0.54) | LMNASMN1; SMN2POLBHTTNCOA1 | |
| SCHEMBL2124279 | 0.75 | PIK3CA (0.43) | LMNASMN1; SMN2POLBHTTNCOA1 | |
| SCHEMBL28732551 | 0.75 | LMNA (0.52) | LMNASMN1; SMN2POLBHTTNCOA1 | |
| SCHEMBL29463392 | 0.75 | LMNA (0.52) | LMNASMN1; SMN2POLBHTTNCOA1 | |
| SCHEMBL30492152 | 0.75 | NT5E (0.66) | LMNASMN1; SMN2POLBHTTNCOA1 | |
| SCHEMBL1536650 | 0.75 | NT5E (0.66) | LMNASMN1; SMN2POLBHTTNCOA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009003164-A1 | COMPOSITIONS COMPRISING INDOLEAMINE 2,3- DIOXYGENASE-2 AND COENZYME Q INHIBITORS AND METHODS OF USE THEREOF | LANKENAU INSTITUTE FOR MEDICAL RESEARCH DEVELOPMENT, INC. (US) | 2008-12-31 | — | — | WO | disclosed |