SCHEMBL5086016

SCHEMBL5086016

CCCc1cc(Cl)cc2c1OC(C(F)(F)F)C(C(=O)O)=C2

nearest known ligand 0.73

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 20/20 0.73
PTGS1 P23219 12/20 0.70

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6093185 0.93 PTGS2 (0.76) PTGS2PTGS1
SCHEMBL14460115 0.93 PTGS2 (0.76) PTGS2PTGS1
SCHEMBL213782 0.93 PTGS2 (0.76) PTGS2PTGS1
SCHEMBL5668322 0.92 PTGS2 (0.69) PTGS2PTGS1
SCHEMBL6092724 0.88 PTGS2 (0.72) PTGS2PTGS1
SCHEMBL6094167 0.88 PTGS2 (0.72) PTGS2PTGS1
SCHEMBL6092011 0.86 PTGS2 (0.67) PTGS2PTGS1
SCHEMBL6092019 0.86 PTGS2 (0.67) PTGS2PTGS1
SCHEMBL5645371 0.85 PTGS2 (0.74) PTGS2PTGS1
SCHEMBL20825829 0.85 PTGS2 (0.73) PTGS2PTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1536863-A1 USE OF CYCLOOXYGENASE-2 SELECTIVE INHIBITORS AND THROMBOLYTIC AGENTS FOR THE TREATMENT OR PREVENTION OF A VASO-OCCLUSIVE EVENT Pharmacia Corporation (US) 2005-06-08 EP claimed
EP-1463500-A1 USE OF COX-2 INHIBITORS IN COMBINATION WITH ANTIVIRAL AGENTS FOR THE TREATMENT OF PAPILLOMA VIRUS INFECTIONS PHARMACIA & UPJOHN COMPANY (US) 2004-10-06 EP claimed
EP-1414526-A2 ANTIANGIOGENIC COMBINATION THERAPY FOR THE TREATMENT OF CANCER Pharmacia Corporation (US) 2004-05-06 EP claimed
EP-1406696-A1 USE OF COMPOSITIONS COMPRISING CYCLOOXYGENASE-2 SELECTIVE INHIBITORS IN COMBINATION WITH RADIATION FOR INHIBITION OR PREVENTION OF CARDIOVASCULAR DISEASE Pharmacia Corporation (US) 2004-04-14 EP claimed
WO-2004004833-A1 USE OF CYCLOOXYGENASE-2 SELECTIVE INHIBITORS AND THROMBOLYTIC AGENTS FOR THE TREATMENT OR PREVENTION OF A VASO-OCCLUSIVE EVENT PHARMACIA CORPORATION (US) 2004-01-15 WO claimed
WO-2003059347-A1 USE OF COX-2 INHIBITORS IN COMBINATION WITH ANTIVIRAL AGENTS FOR THE TREATMENT OF PAPILLOMA VIRUS INFECTIONS PHARMACIA & UPJOHN COMPANY (US) 2003-07-24 WO claimed
WO-2002096516-A1 USE OF COMPOSITIONS COMPRISING CYCLOOXYGENASE-2 SELECTIVE INHIBITORS IN COMBINATION WITH RADIATION FOR INHIBITION OR PREVENTION OF CARDIOVASCULAR DISEASE PHARMACIA CORPORATION (US) 2002-12-05 WO claimed
WO-2002085459-A2 ANTIANGIOGENIC COMBINATION THERAPY FOR THE TREATMENT OF CANCER PHARMACIA CORPORATION (US) 2002-10-31 WO claimed
WO-2018187698-A2 COMBINATION THERAPIES USING CASPASE-1 DEPENDENT ANTICANCER AGENTS AND PGE2 ANTAGONISTS TRUSTEES OF TUFTS COLLEGE (US) 2018-10-11 WO disclosed
WO-2008008549-A2 COMBINATION OF AN IMMUNOSUPPRESSIVE AGENT AND NONSTEROIDAL ANTI -INFLAMMATORY DRUGS TO TREAT NEOPLASIA BOSTON MEDICAL CENTER CORPORATION (US) 2008-01-17 WO disclosed
EP-1608361-A4 COMPOSITIONS OF CYCLOOXYGENASE-2 SELECTIVE INHIBITORS AND 5-HT1B/1D AGONISTS FOR THE TREATMENT AND PREVENTION OF MIGRAINE PHARMACIA CORP (US) 2006-08-16 EP disclosed
EP-1653967-A2 COMBINATION OF A COX-2 INHIBITOR AND AN ALKYLATING-TYPE ANTINEOPLASTIC AGENT FOR TREATMENT OF NEOPLASIA Pharmacia Corporation (US) 2006-05-10 EP disclosed
EP-1653940-A1 THERAPEUTIC COMBINATION OF A COX-2 INHIBITOR AND AN AROMATASE INHIBITOR Pharmacia Corporation (US) 2006-05-10 EP disclosed
EP-1608361-A2 COMPOSITIONS OF CYCLOOXYGENASE-2 SELECTIVE INHIBITORS AND 5-HT1B/1D AGONISTS FOR THE TREATMENT AND PREVENTION OF MIGRAINE Pharmacia Corporation (US) 2005-12-28 EP disclosed
WO-2003092691-A1 COMBINATION OF CYCLOOXYGENASE-2 INHIBITORS AND THALIDOMIDE FOR THE TREATMENT OF NEOPLASIA PHARMACIA COPORATION (US) 2003-11-13 WO disclosed
WO-2003059347-A1 USE OF COX-2 INHIBITORS IN COMBINATION WITH ANTIVIRAL AGENTS FOR THE TREATMENT OF PAPILLOMA VIRUS INFECTIONS PHARMACIA & UPJOHN COMPANY (US) 2003-07-24 WO disclosed
WO-2003020268-A1 METHOD FOR THE TREATMENT AND PREVENTION OF CACHEXIA WASHINGTON UNIVERSITY (US) 2003-03-13 WO disclosed
WO-2002096516-A1 USE OF COMPOSITIONS COMPRISING CYCLOOXYGENASE-2 SELECTIVE INHIBITORS IN COMBINATION WITH RADIATION FOR INHIBITION OR PREVENTION OF CARDIOVASCULAR DISEASE PHARMACIA CORPORATION (US) 2002-12-05 WO disclosed
WO-2002085459-A2 ANTIANGIOGENIC COMBINATION THERAPY FOR THE TREATMENT OF CANCER PHARMACIA CORPORATION (US) 2002-10-31 WO disclosed
WO-2002076395-A2 AGENTS AND METHODS FOR TREATMENT OF CANCER PHARMACIA CORPORATION (US) 2002-10-03 WO disclosed