Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 4/20 | 0.37 |
| ▸ | NR3C2 | P08235 | 8/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.32 |
| ▸ | CCKAR | P32238 | 1/20 | 0.32 |
| ▸ | CCKBR | P32239 | 1/20 | 0.32 |
| ▸ | GPR139 | Q6DWJ6 | 3/20 | 0.31 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.30 |
| ▸ | AURKA | O14965 | 1/20 | 0.30 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5086048 | 1.00 | P2RX7 (0.37) | P2RX7NR3C2PGRNR3C1CCKAR | |
| SCHEMBL1590581 | 0.88 | P2RX7 (0.40) | P2RX7NR3C2GPR139 | |
| SCHEMBL1590582 | 0.88 | P2RX7 (0.40) | P2RX7NR3C2GPR139 | |
| SCHEMBL1589917 | 0.81 | P2RX7 (0.41) | P2RX7GPR139 | |
| SCHEMBL13135963 | 0.80 | NR3C2 (0.38) | P2RX7NR3C2GPR139 | |
| SCHEMBL1590573 | 0.80 | P2RX7 (0.40) | P2RX7GPR139 | |
| SCHEMBL1591156 | 0.78 | P2RX7 (0.39) | P2RX7NR3C2 | |
| SCHEMBL1590006 | 0.76 | PARP1 (0.38) | — | |
| SCHEMBL1590007 | 0.76 | PARP1 (0.38) | — | |
| SCHEMBL13114656 | 0.75 | P2RX7 (0.40) | P2RX7GPR139 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1933622-A2 | BICYCLOHETEROARYL COMPOUNDS AS P2X7 MODULATORS AND USES THEREOF | Renovis, Inc. (US) | 2008-06-25 | — | — | EP | disclosed |
| WO-2007109192-A2 | BICYCLOHETEROARYL COMPOUNDS AS P2X7 MODULATORS AND USES THEREOF | RENOVIS, INC. (US) | 2007-09-27 | — | — | WO | disclosed |