Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPRT1 | P00492 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 14/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 12/20 | 0.36 |
| ▸ | CDK1 | P06493 | 15/20 | 0.36 |
| ▸ | CDK7 | P50613 | 13/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 11/20 | 0.36 |
| ▸ | CCNH | P51946 | 10/20 | 0.36 |
| ▸ | CDK4 | P11802 | 9/20 | 0.36 |
| ▸ | CCND1 | P24385 | 9/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 6/20 | 0.35 |
| ▸ | CDK9 | P50750 | 4/20 | 0.35 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.35 |
| ▸ | CLK2 | P49760 | 2/20 | 0.35 |
| ▸ | CSNK1G2 | P78368 | 2/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.35 |
| ▸ | CSNK1G1 | Q9HCP0 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5082999 | 0.89 | HPRT1 (0.40) | HPRT1CDK2CCNE1CDK1CCNB1 | |
| SCHEMBL5082380 | 0.87 | HPRT1 (0.38) | HPRT1CDK2CCNE1CDK1CCNB1 | |
| SCHEMBL5086113 | 0.85 | HPRT1 (0.35) | HPRT1CDK2CCNE1CDK1CCNB1 | |
| SCHEMBL5083699 | 0.85 | CDK1 (0.41) | CDK2CCNE1CDK1CDK7CCNB1 | |
| SCHEMBL5080084 | 0.83 | HPRT1 (0.35) | HPRT1CDK2CCNE1CDK1CCNB1 | |
| SCHEMBL5083570 | 0.81 | CDK1 (0.34) | CDK2CCNE1CDK1CDK7CCNB1 | |
| SCHEMBL5085976 | 0.80 | HPRT1 (0.32) | HPRT1CDK2CCNE1CDK1CCNB1 | |
| SCHEMBL5083541 | 0.79 | NT5E (0.33) | — | |
| SCHEMBL5082395 | 0.78 | CDK1 (0.35) | CDK2CCNE1CDK1CDK7CCNB1 | |
| SCHEMBL5082981 | 0.77 | CCNE2 (0.34) | HPRT1CDK2CCNE1CDK1CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7388002-B2 | Nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases | BIOCRYST PHARMACEUTICALS, INC. (US) | 2008-06-17 | — | — | US | disclosed |
| US-20060122391-A1 | Nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases | BIOCRYST PHARMACEUTICALS, INC. (US) | 2006-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060122391-A1 | Nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases | POLR2H, NSUN2, POLR2E | HPRT1 319/4885CDK2 339/4885CCNE1 440/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.