SCHEMBL5086281

SCHEMBL5086281

CCc1cc(C(F)(F)C(F)(F)F)n[nH]1

nearest known ligand 0.42

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 1/20 0.42
HPGD P15428 1/20 0.39
TSHR P16473 1/20 0.39
COMT P21964 1/20 0.37
CCNA2 P20248 1/20 0.32
CDK2 P24941 1/20 0.32
CCNA1 P78396 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2581322 0.84 HCAR2 (0.44) HCAR2HPGDTSHRCOMTCCNA2
SCHEMBL1206509 0.79 HPGD (0.56) HCAR2HPGDTSHRCOMTCCNA2
SCHEMBL14037797 0.74 HCAR2 (0.47) HCAR2HPGDTSHRCOMTCCNA2
SCHEMBL1833452 0.71 MCL1 (0.46) HPGD
SCHEMBL24008018 0.69 MCL1 (0.31)
SCHEMBL13206417 0.69 ALOX15 (0.40) HPGD
SCHEMBL2876826 0.69 HCAR2 (0.47) HCAR2HPGDTSHRCCNA2CDK2
SCHEMBL21737077 0.69
SCHEMBL2870668 0.67 HCAR2 (0.50) HCAR2HPGDTSHR
SCHEMBL1120133 0.67 MCL1 (0.42) HPGDTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008091594-A2 FUNGICIDAL MIXTURES E. I. DU PONT DE NEMOURS AND COMPANY (US) 2008-07-31 WO disclosed