Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 13/20 | 0.87 |
| ▸ | BRAF | P15056 | 7/20 | 0.87 |
| ▸ | KDR | P35968 | 5/20 | 0.87 |
| ▸ | RET | P07949 | 3/20 | 0.87 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.87 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.87 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.87 |
| ▸ | ABL1 | P00519 | 2/20 | 0.87 |
| ▸ | HTR1A | P08908 | 2/20 | 0.87 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.87 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.87 |
| ▸ | KIT | P10721 | 2/20 | 0.87 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.87 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.87 |
| ▸ | FLT1 | P17948 | 2/20 | 0.87 |
| ▸ | MAOA | P21397 | 2/20 | 0.87 |
| ▸ | EPHA1 | P21709 | 2/20 | 0.87 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.87 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.87 |
| ▸ | TTK | P33981 | 2/20 | 0.87 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Regorafenib SCHEMBL29349808 | 0.93 | RAF1 (1.00) | RAF1BRAFKDRRETEPHX2 | |
| Regorafenib SCHEMBL432230 | 0.93 | RAF1 (1.00) | RAF1BRAFKDRRETEPHX2 | |
| Regorafenib SCHEMBL29351376 | 0.93 | RAF1 (1.00) | RAF1BRAFKDRRETEPHX2 | |
| SCHEMBL620651 | 0.93 | RAF1 (0.84) | RAF1BRAFKDRRETEPHX2 | |
| Sorafenib SCHEMBL8218 | 0.93 | RAF1 (1.00) | RAF1BRAFKDRRETEPHX2 | |
| Sorafenib SCHEMBL29349634 | 0.93 | RAF1 (1.00) | RAF1BRAFKDRRETEPHX2 | |
| Sorafenib SCHEMBL14739751 | 0.93 | RAF1 (1.00) | RAF1BRAFKDRRETEPHX2 | |
| Regorafenib SCHEMBL2555101 | 0.92 | RAF1 (0.98) | RAF1BRAFKDRRETEPHX2 | |
| SCHEMBL20812478 | 0.92 | RAF1 (0.82) | RAF1BRAFKDRRETEPHX2 | |
| Regorafenib SCHEMBL29496390 | 0.92 | RAF1 (0.98) | RAF1BRAFKDRRETEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1636585-B2 | DIARYL UREAS WITH KINASE INHIBITING ACTIVITY | BAYER HEALTHCARE LLC (US) | 2012-06-13 | — | — | EP | claimed |
| EP-1636585-B1 | DIARYL UREAS WITH KINASE INHIBITING ACTIVITY | BAYER PHARMACEUTICALS CORP (US) | 2008-01-16 | — | — | EP | claimed |
| EP-1626714-B1 | DIARYL UREAS FOR DISEASES MEDIATED BY PDGFR | BAYER PHARMACEUTICALS CORP (US) | 2007-07-04 | — | — | EP | claimed |
| JP-2007511203-A | — | — | 2007-05-10 | — | — | JP | claimed |
| US-20070020704-A1 | Diaryl ureas with kinase inhibiting activity | BAYER HEALTHCARE LLC | 2007-01-25 | — | — | US | claimed |
| EP-1636585-A2 | DIARYL UREAS WITH KINASE INHIBITING ACTIVITY | Bayer Pharmaceuticals Corporation (US) | 2006-03-22 | — | — | EP | claimed |
| EP-1140840-B1 | -G(V)-CARBOXYARYL SUBSTITUTED DIPHENYL UREAS AS RAF KINASE INHIBITORS | BAYER PHARMACEUTICALS CORP (US) | 2006-03-22 | — | — | EP | claimed |
| EP-1626714-A2 | DIARYL UREAS FOR DISEASES MEDIATED BY PDGFR | Bayer Pharmaceuticals Corporation (US) | 2006-02-22 | — | — | EP | claimed |
| US-20050059703-A1 | Treating, ameliorating, preventing, or modulating restenosis following angioplastic surgery, injure the vascular system; a salt of N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl) urea; intravascular stent is impregnated with the compound to inhibit restenosis | BAYER HEALTHCARE LLC | 2005-03-17 | — | — | US | claimed |
| WO-2005000284-A2 | DIARYL UREAS FOR DISEASES MEDIATED BY PDGFR | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-01-06 | — | — | WO | claimed |
| WO-2004113274-A2 | DIARYL UREAS WITH KINASE INHIBITING ACTIVITY | BAYER PHARMACEUTICALS CORPORATION (US) | 2004-12-29 | — | — | WO | claimed |
| US-8796250-B2 | Diaryl ureas for diseases mediated by PDGFR | BAYER HEALTHCARE LLC (US) | 2014-08-05 | — | — | US | disclosed |
| EP-1626714-B1 | DIARYL UREAS FOR DISEASES MEDIATED BY PDGFR | BAYER PHARMACEUTICALS CORP (US) | 2007-07-04 | — | — | EP | disclosed |
| EP-1140840-B1 | -G(V)-CARBOXYARYL SUBSTITUTED DIPHENYL UREAS AS RAF KINASE INHIBITORS | BAYER PHARMACEUTICALS CORP (US) | 2006-03-22 | — | — | EP | disclosed |
| EP-1626714-A2 | DIARYL UREAS FOR DISEASES MEDIATED BY PDGFR | Bayer Pharmaceuticals Corporation (US) | 2006-02-22 | — | — | EP | disclosed |
| US-20050059703-A1 | Treating, ameliorating, preventing, or modulating restenosis following angioplastic surgery, injure the vascular system; a salt of N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl) urea; intravascular stent is impregnated with the compound to inhibit restenosis | BAYER HEALTHCARE LLC | 2005-03-17 | — | — | US | disclosed |
| WO-2005000284-A2 | DIARYL UREAS FOR DISEASES MEDIATED BY PDGFR | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-01-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050059703-A1 | Treating, ameliorating, preventing, or modulating restenosis following angioplastic surgery, injure the vascular system; a salt of N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl) urea; intravascular stent is impregnated with the compound to inhibit restenosis | PDGFRB, PDGFRA, PDGFA | RAF1 761/4885BRAF 1489/4885KDR 14/4885 |
| US-20070020704-A1 | Diaryl ureas with kinase inhibiting activity | FLT4, FLT1, FLT3 | RAF1 51/4885BRAF 31/4885KDR 44/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.