Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 16/20 | 0.68 |
| ▸ | MAPK13 | O15264 | 12/20 | 0.64 |
| ▸ | MAPK12 | P53778 | 12/20 | 0.64 |
| ▸ | MAPK11 | Q15759 | 12/20 | 0.64 |
| ▸ | JAK2 | O60674 | 1/20 | 0.59 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.57 |
| ▸ | CDK8 | P49336 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1011007 | 0.86 | MAPK14 (0.60) | MAPK14MAPK13MAPK12MAPK11JAK2 | |
| SCHEMBL1012719 | 0.86 | MAPK13 (0.78) | MAPK14MAPK13MAPK12MAPK11JAK2 | |
| SCHEMBL3621438 | 0.85 | CDK8 (0.67) | MAPK14MAPK13MAPK12MAPK11JAK2 | |
| SCHEMBL5734057 | 0.83 | MAPK14 (0.80) | MAPK14MAPK13MAPK12MAPK11DDR2 | |
| SCHEMBL4420318 | 0.82 | MAPK14 (0.60) | MAPK14MAPK13MAPK12MAPK11JAK2 | |
| SCHEMBL2314764 | 0.82 | GRN (0.74) | MAPK14MAPK13MAPK12MAPK11GAA | |
| SCHEMBL20569742 | 0.81 | MAP3K7 (0.61) | MAPK14MAPK13MAPK12MAPK11JAK2 | |
| SCHEMBL5732718 | 0.81 | MAPK14 (1.00) | MAPK14MAPK11 | |
| SCHEMBL1600309 | 0.81 | CDK8 (0.82) | MAPK14MAPK13MAPK12MAPK11JAK2 | |
| SCHEMBL4080679 | 0.80 | MAPK14 (0.61) | MAPK14MAPK13MAPK12MAPK11JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3074395-A1 | PROCESS FOR THE PREPARATION OF 8-(4-AMINOPHENOXY)-4H-PYRIDO[2,3-B]PYRAZIN-3-ONE DERIVATIVES | Cancer Research Technology Ltd (GB) | 2016-10-05 | — | — | EP | disclosed |
| WO-2015075482-A1 | PROCESS FOR THE PREPARATION OF 8-(4-AMINOPHENOXY)-4H-PYRIDO[2,3-B]PYRAZIN-3-ONE DERIVATIVES | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2015-05-28 | — | — | WO | disclosed |
| EP-1987022-A1 | PYRIDINONE PYRAZOLE UREA AND PYRIMIDINONE PYRAZOLE UREA DERIVATIVES | Pfizer Products Inc. (US) | 2008-11-05 | — | — | EP | disclosed |
| WO-2007091176-A1 | PYRIDINONE PYRAZOLE UREA AND PYRIMIDINONE PYRAZOLE UREA DERIVATIVES | PFIZER PRODUCTS INC. (US) | 2007-08-16 | — | — | WO | disclosed |