SCHEMBL5087332

SCHEMBL5087332

COc1c([Si](C)(C)C2=Cc3ccccc3C2)cc(C)cc1[Si](C)(C)C(C)(C)C

nearest known ligand 0.38

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 3/20 0.38
ADRA2A P08913 1/20 0.31
ADRA2B P18089 1/20 0.31
ADRA2C P18825 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5090569 0.88 PTGS2 (0.39) PTGS2ADRA2AADRA2BADRA2C
SCHEMBL5083926 0.86 PTGS2 (0.36) PTGS2
SCHEMBL5083923 0.85 PTGS2 (0.39) PTGS2ADRA2AADRA2BADRA2C
SCHEMBL5085743 0.84
SCHEMBL5090614 0.81 PTGS2 (0.38) PTGS2ADRA2AADRA2BADRA2C
SCHEMBL5090416 0.77 PTGS2 (0.36) PTGS2
SCHEMBL5087107 0.77 PTGS2 (0.36) PTGS2
SCHEMBL5086931 0.76 PTGS2 (0.35) PTGS2
SCHEMBL5083876 0.76 CYP3A4 (0.32)
SCHEMBL5083842 0.75 PTGS2 (0.40) PTGS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1498178-B1 Transition metal complex and process for producing the same SUMITOMO CHEMICAL CO (JP) 2008-06-11 EP disclosed
EP-1498178-A2 Transition metal complex, process for producing the same, olefin polymerization catalyst containing the transition metal complex and process for producing olefin polymers Sumitomo Chemical Company, Limited (JP) 2005-01-19 EP disclosed
EP-0842939-B1 OLEFIN POLYMERIZATION CATALYST CONTAINING A TRANSITION METAL COMPLEX AND PROCESS FOR PRODUCING OLEFIN POLYMERS SUMITOMO CHEMICAL CO (JP) 2004-10-06 EP disclosed
US-6329478-B1 SOLUBILITY IN SATURATED HYDROCARBON SOLVENTS SUMITMO CHEMICAL COMPANY, LIMITED 2001-12-11 US disclosed
EP-0842939-A1 TRANSITION METAL COMPLEX, PROCESS FOR THE PREPARATION THEREOF, POLYMERIZATION CATALYST FOR OLEFINS CONTAINING THE COMPLEX, AND PROCESS FOR PRODUCING OLEFIN POLYMERS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1998-05-20 EP disclosed