Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.34 |
| ▸ | ADH1B | P00325 | 1/20 | 0.34 |
| ▸ | ADH1C | P00326 | 1/20 | 0.34 |
| ▸ | ADH1A | P07327 | 1/20 | 0.34 |
| ▸ | ADH4 | P08319 | 1/20 | 0.34 |
| ▸ | ADH7 | P40394 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.33 |
| ▸ | FDPS | P14324 | 3/20 | 0.32 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL2761553 | 1.00 | OPRM1 (0.38) | OPRM1SPHK1LMNADNM1ADH1B | |
| Bromide SCHEMBL5093234 | 1.00 | OPRM1 (0.38) | OPRM1SPHK1LMNADNM1ADH1B | |
| Hydrochloric Acid SCHEMBL5085303 | 0.98 | OPRM1 (0.39) | OPRM1SPHK1LMNADNM1ADH1B | |
| Hydrochloric Acid SCHEMBL5087852 | 0.98 | OPRM1 (0.39) | OPRM1SPHK1LMNADNM1ADH1B | |
| Hydrochloric Acid SCHEMBL5087957 | 0.98 | OPRM1 (0.39) | OPRM1SPHK1LMNADNM1ADH1B | |
| Bromide SCHEMBL5093292 | 0.98 | OPRM1 (0.39) | OPRM1SPHK1LMNADNM1ADH1B | |
| Iodide SCHEMBL5085166 | 0.96 | OPRM1 (0.38) | OPRM1SPHK1LMNADNM1ADH1B | |
| Iodide SCHEMBL5088272 | 0.96 | OPRM1 (0.38) | OPRM1SPHK1LMNADNM1ADH1B | |
| Iodide SCHEMBL5091735 | 0.96 | OPRM1 (0.38) | OPRM1SPHK1LMNADNM1ADH1B | |
| Hydrochloric Acid SCHEMBL5093080 | 0.96 | OPRM1 (0.41) | OPRM1SPHK1LMNADNM1ADH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080214386-A1 | Stability; easily separated from solution; surface treatment of catalyst with Group seven compound; reacting epoxide with carbon dioxide | NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY (JP) | 2008-09-04 | — | — | US | disclosed |