Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAALAD2 | Q9Y3Q0 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 5/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | USP5 | P45974 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.40 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.39 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.39 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.38 |
| ▸ | GABRP | O00591 | 2/20 | 0.37 |
| ▸ | GABRD | O14764 | 2/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.37 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL223316 | 0.88 | NAALAD2 (0.53) | NAALAD2CYP1A2CNR1CNR2ESR1 | |
| Propionic Acid SCHEMBL11111085 | 0.84 | NAALAD2 (0.48) | NAALAD2CYP1A2CNR1CNR2ESR1 | |
| SCHEMBL1433579 | 0.79 | ESR1 (0.50) | NAALAD2CYP1A2ESR1ESR2ALDH1A1 | |
| Propylene Glycol SCHEMBL10345908 | 0.77 | ESR1 (0.52) | CYP1A2ESR1ESR2ALDH1A1CYP3A4 | |
| SCHEMBL2538851 | 0.77 | TBXAS1 (0.47) | NAALAD2CNR1CNR2ESR1ESR2 | |
| SCHEMBL4581773 | 0.76 | CNR1 (0.38) | CYP1A2CNR1CNR2ESR1ESR2 | |
| SCHEMBL51338 | 0.75 | TBXAS1 (0.54) | NAALAD2CNR1CNR2ESR1ESR2 | |
| SCHEMBL8402189 | 0.74 | KMT2A (0.52) | CYP1A2CNR1CNR2USP5 | |
| SCHEMBL9092531 | 0.74 | TBXAS1 (0.56) | NAALAD2CNR1CNR2 | |
| SCHEMBL9092430 | 0.74 | TBXAS1 (0.56) | NAALAD2CNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080203012-A1 | MEMBRANE, APPARATUS, AND ASSOCIATED METHOD | GENERAL ELECTRIC COMPANY (US) | 2008-08-28 | — | — | US | disclosed |