Niacinamide

Niacinamide

SCHEMBL508960

NC(=O)c1cccnc1.[O]

nearest known ligand 0.96

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
F7 P08709 1/20 0.96
F3 P13726 1/20 0.96
SARM1 Q6SZW1 1/20 0.96
SIRT2 Q8IXJ6 1/20 0.96
SIRT6 Q8N6T7 1/20 0.96
SIRT1 Q96EB6 1/20 0.96
SIRT3 Q9NTG7 1/20 0.96
SIRT5 Q9NXA8 1/20 0.96
SIRT4 Q9Y6E7 1/20 0.96
ALDH1A1 P00352 2/20 0.63
APP P05067 1/20 0.63
GAA P10253 1/20 0.63
HCAR3 P49019 1/20 0.63
HCAR2 Q8TDS4 1/20 0.63
MKNK1 Q9BUB5 3/20 0.61
MKNK2 Q9HBH9 3/20 0.61
HDAC1 Q13547 2/20 0.57
HDAC6 Q9UBN7 1/20 0.57
POLB P06746 2/20 0.53
PLOD2 O00469 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Niacinamide SCHEMBL2926 0.98
Niacinamide SCHEMBL29624874 0.98
Niacinamide SCHEMBL19978192 0.98
Niacinamide SCHEMBL460466 0.98 F7 (1.00) F7F3SARM1SIRT2SIRT6
Niacinamide SCHEMBL23576525 0.96 F7 (0.96) F7F3SARM1SIRT2SIRT6
Niacinamide SCHEMBL11870926 0.96 F7 (0.96) F7F3SARM1SIRT2SIRT6
Niacinamide SCHEMBL9373225 0.96 F7 (0.96) F7F3SARM1SIRT2SIRT6
Niacinamide SCHEMBL1220080 0.96 F7 (0.96) F7F3SARM1SIRT2SIRT6
Niacinamide SCHEMBL6702885 0.96 F7 (0.96) F7F3SARM1SIRT2SIRT6
Niacinamide SCHEMBL226257 0.96 F7 (0.96) F7F3SARM1SIRT2SIRT6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9109200-B2 Use of enzymes to reduce aldehydes from aldehyde-containing products BASF SE (DE) 2015-08-18 US disclosed
EP-2417253-A1 USE OF ENZYMES TO REDUCE ALDEHYDES FROM ALDEHYDE-CONTAINING PRODUCTS BASF SE (DE) 2012-02-15 EP disclosed
US-20120028333-A1 USE OF ENZYMES TO REDUCE ALDEHYDES FROM ALDEHYDE-CONTAINING PRODUCTS BASF SE (DE) 2012-02-02 US disclosed
WO-2010115797-A1 USE OF ENZYMES TO REDUCE ALDEHYDES FROM ALDEHYDE-CONTAINING PRODUCTS BASF SE (DE) 2010-10-14 WO disclosed
US-7083961-B1 Crystal structures of T. foetus inosine monophosphate dehydrogenase in complex with substrate, cofactor and analogs and uses thereof REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2006-08-01 US disclosed