Niacinamide

Niacinamide

SCHEMBL2271609

NC(=O)c1cccnc1.[Zn]

nearest known ligand 0.96

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
F7 P08709 1/20 0.96
F3 P13726 1/20 0.96
SARM1 Q6SZW1 1/20 0.96
SIRT2 Q8IXJ6 1/20 0.96
SIRT6 Q8N6T7 1/20 0.96
SIRT1 Q96EB6 1/20 0.96
SIRT3 Q9NTG7 1/20 0.96
SIRT5 Q9NXA8 1/20 0.96
SIRT4 Q9Y6E7 1/20 0.96
ALDH1A1 P00352 2/20 0.63
APP P05067 1/20 0.63
GAA P10253 1/20 0.63
HCAR3 P49019 1/20 0.63
HCAR2 Q8TDS4 1/20 0.63
MKNK1 Q9BUB5 3/20 0.61
MKNK2 Q9HBH9 3/20 0.61
HDAC1 Q13547 2/20 0.57
HDAC6 Q9UBN7 1/20 0.57
POLB P06746 2/20 0.53
PLOD2 O00469 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Niacinamide SCHEMBL9373225 1.00 F7 (0.96) F7F3SARM1SIRT2SIRT6
Niacinamide SCHEMBL2926 0.98
Niacinamide SCHEMBL19978192 0.98
Niacinamide SCHEMBL29624874 0.98
Niacinamide SCHEMBL460466 0.98 F7 (1.00) F7F3SARM1SIRT2SIRT6
Niacinamide SCHEMBL23576525 0.96 F7 (0.96) F7F3SARM1SIRT2SIRT6
Niacinamide SCHEMBL1220080 0.96 F7 (0.96) F7F3SARM1SIRT2SIRT6
Niacinamide SCHEMBL6702885 0.96 F7 (0.96) F7F3SARM1SIRT2SIRT6
Niacinamide SCHEMBL11870926 0.96 F7 (0.96) F7F3SARM1SIRT2SIRT6
Niacinamide SCHEMBL9949818 0.96 F7 (0.96) F7F3SARM1SIRT2SIRT6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114794469-A Compositions for inhibiting melanin and uses and methods thereof 桂格燕麦公司 2022-07-29 CN claimed
EP-0589047-B1 METHOD OF TREATING INFECTIOUS DISEASE, METHOD OF PREVENTING PUTREFACTION OF COSMETIC, AND ANTIBACTERIAL/ANTIFUNGAL AGENT AND COSMETIC OTSUKA PHARMA CO LTD (JP) 1999-06-09 EP claimed
US-5696169-A CONTAINING A ZINC COMPOUND AND HINOKITIOL OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1997-12-09 US claimed
EP-0589047-A1 METHOD OF TREATING INFECTIOUS DISEASE, METHOD OF PREVENTING PUTREFACTION OF COSMETIC, AND ANTIBACTERIAL/ANTIFUNGAL AGENT AND COSMETIC OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1994-03-30 EP claimed
CN-115835904-A ADAMTS13 compositions and methods for the treatment and diagnosis of coronary viral disease complications 武田药品工业有限公司 2023-03-21 CN disclosed
CN-114794469-A Compositions for inhibiting melanin and uses and methods thereof 桂格燕麦公司 2022-07-29 CN disclosed
EP-3681461-B1 AN ANTIMICROBIAL COMPOSITION UNILEVER NV (NL) 2021-03-17 EP disclosed
US-20200360249-A1 AN ANTIMICROBIAL COMPOSITION CONOPCO INC DBA UNILEVER (US) 2020-11-19 US disclosed
US-20200345767-A1 Fast Acting Inhibitor of Gastric Acid Secretion UNIV YALE (US) 2020-11-05 US disclosed
US-10603339-B2 Fast acting inhibitor of gastric acid secretion YALE UNIVERSITY (US) 2020-03-31 US disclosed
EP-2182947-B1 COMPOSITIONS WITH ENHANCED BIOAVAILABILITY AND FAST ACTING INHIBITOR OF GASTRIC ACID SECRETION UNIV YALE (US) 2019-09-04 EP disclosed
US-10278989-B2 Fast acting inhibitor of gastric acid secretion YALE UNIVERSITY (US) 2019-05-07 US disclosed
US-5582817-A ORGANOZINC COMPOUNDS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1996-12-10 US disclosed
CN-1107140-A Acetyl-salicylic derivate combined with niacinamide and zinc HAMI PHARMACEUTIC FACTORY XINJ (CN) 1995-08-23 CN disclosed
EP-0662830-A4 -G(P)-BOND AROMATIC VITAMIN CHELATES. 1995-08-16 EP disclosed
EP-0662830-A1 $g(p)-BOND AROMATIC VITAMIN CHELATES ALBION INTERNATIONAL, INC. (US) 1995-07-19 EP disclosed
EP-0589047-A1 METHOD OF TREATING INFECTIOUS DISEASE, METHOD OF PREVENTING PUTREFACTION OF COSMETIC, AND ANTIBACTERIAL/ANTIFUNGAL AGENT AND COSMETIC OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1994-03-30 EP disclosed
US-5292729-A Pi bond vitamin-mineral chelates ALBION INTERNATIONAL, INC. (US) 1994-03-08 US disclosed
WO-1994004141-A1 π-BOND AROMATIC VITAMIN CHELATES ALBION INTERNATIONAL, INC. (US) 1994-03-03 WO disclosed
EP-0583479-A1 REMEDY FOR DERMATOPATHY AND METALLOTHIONEIN INDUCER OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1994-02-23 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200360249-A1 AN ANTIMICROBIAL COMPOSITION PPOX, CUTA, LPO F7 2479/4885F3 3512/4885SARM1 1645/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.