SCHEMBL5089820

SCHEMBL5089820

CCCCn1ccc2cc(N)ccc21

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PRKCI P41743 1/20 0.56
EGFR P00533 2/20 0.49
PLAU P00749 2/20 0.49
PLG P00747 1/20 0.49
CDK4 P11802 4/20 0.44
CCND1 P24385 4/20 0.44
BRPF1 P55201 1/20 0.44
NTSR1 P30989 1/20 0.43
MAPT P10636 1/20 0.41
HSD17B10 Q99714 1/20 0.41
TLR8 Q9NR97 2/20 0.40
TLR7 Q9NYK1 1/20 0.40
HTR2A P28223 3/20 0.40
HTR2C P28335 3/20 0.40
KDM4E B2RXH2 1/20 0.39
MEN1 O00255 1/20 0.39
ALDH1A1 P00352 1/20 0.39
GAA P10253 1/20 0.39
KMT2A Q03164 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31312599 0.94 PRKCI (0.53) PRKCIEGFRPLAUPLGCDK4
SCHEMBL3650822 0.90 PRKCI (0.59) PRKCIEGFRPLAUPLGCDK4
SCHEMBL27812843 0.87 CDK4 (0.44) PRKCIEGFRPLAUPLGCDK4
SCHEMBL6928247 0.83 PRKCI (0.51) PRKCIEGFRPLAUPLGHTR2A
SCHEMBL218056 0.82 PRKCI (0.58) PRKCIEGFRPLAUBRPF1NTSR1
SCHEMBL31265088 0.82 PRKCI (0.58) PRKCIEGFRPLAUBRPF1NTSR1
SCHEMBL18856946 0.81 HTR2A (0.55) PLAUPLGCDK4CCND1MAPT
SCHEMBL6789563 0.81 PRKCI (0.56) PRKCIEGFRPLAUPLGCDK4
Hydrochloric Acid SCHEMBL7361184 0.81 PRKCI (0.56) PRKCIEGFRPLAUBRPF1NTSR1
SCHEMBL18856955 0.80 HTR2A (0.56) PLAUPLGCDK4CCND1HTR2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108349930-A Substituted Tricycles and Methods of Use 艾伯维公司 2018-07-31 CN disclosed
EP-2007756-A2 MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS Vertex Pharmceuticals Incorporated (US) 2008-12-31 EP disclosed
WO-2007117715-A2 MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS VERTEX PHARMACEUTICALS INCORPORATED (US) 2007-10-18 WO disclosed