Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 1/20 | 0.59 |
| ▸ | EGFR | P00533 | 2/20 | 0.57 |
| ▸ | BRPF1 | P55201 | 2/20 | 0.46 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.45 |
| ▸ | PLAU | P00749 | 2/20 | 0.44 |
| ▸ | PLG | P00747 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 5/20 | 0.41 |
| ▸ | HTR2A | P28223 | 4/20 | 0.41 |
| ▸ | CDK4 | P11802 | 2/20 | 0.41 |
| ▸ | CCND1 | P24385 | 2/20 | 0.41 |
| ▸ | PDE5A | O76074 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5089820 | 0.90 | PRKCI (0.56) | PRKCIEGFRBRPF1NTSR1PLAU | |
| SCHEMBL24418057 | 0.87 | EGFR (0.50) | PRKCIEGFRNTSR1PLAUPLG | |
| SCHEMBL31312599 | 0.87 | PRKCI (0.53) | PRKCIEGFRBRPF1NTSR1PLAU | |
| SCHEMBL8648989 | 0.86 | EGFR (0.48) | PRKCIEGFRBRPF1HTR2CHTR2A | |
| SCHEMBL218056 | 0.85 | PRKCI (0.58) | PRKCIEGFRBRPF1NTSR1PLAU | |
| SCHEMBL31265088 | 0.85 | PRKCI (0.58) | PRKCIEGFRBRPF1NTSR1PLAU | |
| Hydrochloric Acid SCHEMBL7361184 | 0.84 | PRKCI (0.56) | PRKCIEGFRBRPF1NTSR1PLAU | |
| SCHEMBL6789563 | 0.84 | PRKCI (0.56) | PRKCIEGFRBRPF1NTSR1PLAU | |
| SCHEMBL13811474 | 0.82 | PRKCI (0.51) | PRKCIEGFRBRPF1NTSR1PLAU | |
| SCHEMBL4007913 | 0.82 | SCN9A (0.55) | PRKCIEGFRBRPF1NTSR1PLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2197875-A1 | DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS | Via Pharmaceuticals, Inc. (US) | 2010-06-23 | — | — | EP | claimed |
| WO-2009037222-A1 | DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS | VIA PHARMACEUTICALS, INC. (US) | 2009-03-26 | — | — | WO | claimed |
| EP-2197875-A1 | DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS | Via Pharmaceuticals, Inc. (US) | 2010-06-23 | — | — | EP | disclosed |
| WO-2009037222-A1 | DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS | VIA PHARMACEUTICALS, INC. (US) | 2009-03-26 | — | — | WO | disclosed |
| US-5328922-A | Anxiolytic and antidepressant activity | BEECHAM GROUP P.L.C. (GB) | 1994-07-12 | — | — | US | disclosed |
| WO-1993018026-A1 | INDOLE UREAS AS 5-HT1C RECEPTOR ANTOGONISTS | BEECHAM GROUP PLC (GB) | 1993-09-16 | — | — | WO | disclosed |
| EP-0550507-A1 | INDOLE UREAS AS 5 HT RECEPTOR ANTAGONIST | Beecham Group p.l.c. (GB) | 1993-07-14 | — | — | EP | disclosed |
| WO-1992005170-A1 | INDOLE UREAS AS 5 HT RECEPTOR ANTAGONIST | BEECHAM GROUP PLC (GB) | 1992-04-02 | — | — | WO | disclosed |