Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES2 | Q9H7Z7 | 8/20 | 0.51 |
| ▸ | ACLY | P53396 | 2/20 | 0.51 |
| ▸ | MAP2K1 | Q02750 | 6/20 | 0.47 |
| ▸ | MAP2K2 | P36507 | 5/20 | 0.47 |
| ▸ | SGK1 | O00141 | 2/20 | 0.44 |
| ▸ | CCR2 | P41597 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2146366 | 0.87 | PTGES2 (0.61) | PTGES2ACLYSGK1 | |
| SCHEMBL391013 | 0.85 | MAP2K1 (0.52) | PTGES2MAP2K1MAP2K2 | |
| SCHEMBL392182 | 0.84 | MAP2K1 (0.49) | ACLYMAP2K1MAP2K2CCR2 | |
| SCHEMBL388160 | 0.80 | MAP2K1 (0.47) | ACLYMAP2K1MAP2K2 | |
| SCHEMBL389927 | 0.80 | MAP2K1 (0.45) | MAP2K1MAP2K2 | |
| SCHEMBL391179 | 0.79 | MAP2K1 (0.57) | MAP2K1MAP2K2 | |
| SCHEMBL9994842 | 0.78 | MAP2K1 (0.47) | MAP2K1MAP2K2BRAF | |
| SCHEMBL901366 | 0.78 | MAP2K1 (0.47) | PTGES2ACLYMAP2K1MAP2K2CCR2 | |
| SCHEMBL392146 | 0.78 | BRD4 (0.46) | MAP2K1MAP2K2 | |
| SCHEMBL391758 | 0.77 | MAP2K1 (0.48) | PTGES2MAP2K1MAP2K2BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912636-A2 | N-(ARYLAMINO)-SULFONAMIDE INHIBITORS OF MEK | Ardea Biosciences, Inc. (US) | 2008-04-23 | — | — | EP | disclosed |
| WO-2007014011-A2 | N-(ARYLAMINO)-SULFONAMIDE INHIBITORS OF MEK | ARDEA BIOSCIENCES, INC. (US) | 2007-02-01 | — | — | WO | disclosed |