Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 15/20 | 0.47 |
| ▸ | MAP2K2 | P36507 | 10/20 | 0.47 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.44 |
| ▸ | ACLY | P53396 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.38 |
| ▸ | CCR1 | P32246 | 1/20 | 0.38 |
| ▸ | CCR2 | P41597 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL388128 | 0.89 | MAP2K1 (0.46) | MAP2K1MAP2K2CA2HDAC3HDAC4 | |
| SCHEMBL391758 | 0.86 | MAP2K1 (0.48) | MAP2K1MAP2K2PTGES2CA2 | |
| SCHEMBL388160 | 0.83 | MAP2K1 (0.47) | MAP2K1MAP2K2ACLYCA2PIM1 | |
| SCHEMBL393218 | 0.82 | THRB (0.59) | MAP2K1MAP2K2CA2HDAC3HDAC4 | |
| SCHEMBL393069 | 0.81 | MAP2K1 (0.48) | MAP2K1MAP2K2CA2PIM1CAMK2B | |
| SCHEMBL9994842 | 0.80 | MAP2K1 (0.47) | MAP2K1MAP2K2CA2PIM1CAMK2B | |
| SCHEMBL685700 | 0.80 | MAP2K1 (0.49) | MAP2K1MAP2K2CA2CCR2 | |
| SCHEMBL392182 | 0.80 | MAP2K1 (0.49) | MAP2K1MAP2K2ACLYCA2CCR2 | |
| SCHEMBL391250 | 0.79 | MAP2K1 (0.48) | MAP2K1MAP2K2CA2HDAC3HDAC4 | |
| SCHEMBL5090048 | 0.78 | PTGES2 (0.51) | MAP2K1MAP2K2PTGES2ACLYCCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2621486-A1 | SUBSTITUTED N-(2-ARYLAMINO)ARYL SULFONAMIDE-CONTAINING COMBINATIONS | Bayer Intellectual Property GmbH (DE) | 2013-08-07 | — | — | EP | claimed |
| WO-2012041987-A1 | SUBSTITUTED N-(2-ARYLAMINO)ARYL SULFONAMIDE-CONTAINING COMBINATIONS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-04-05 | — | — | WO | claimed |