Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 7/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.55 |
| ▸ | HRH2 | P25021 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5031512 | 0.88 | PIK3CB (0.62) | HRH4HRH3HRH2SMN1; SMN2NPSR1 | |
| SCHEMBL1774192 | 0.80 | HRH4 (0.54) | HRH4HRH3HRH2NPSR1EGFR | |
| SCHEMBL2948693 | 0.79 | HRH4 (0.55) | HRH4HRH3HRH2SMN1; SMN2RAB9A | |
| SCHEMBL9215848 | 0.78 | HRH4 (0.56) | HRH4SMN1; SMN2ALDH1A1POLB | |
| SCHEMBL17623030 | 0.78 | HRH4 (0.52) | HRH4HRH3HRH2SMN1; SMN2RAB9A | |
| SCHEMBL27741348 | 0.78 | NPSR1 (0.42) | HRH4HRH3HRH2NPSR1EGFR | |
| SCHEMBL28776132 | 0.78 | NPSR1 (0.42) | HRH4HRH3HRH2NPSR1EGFR | |
| SCHEMBL5144566 | 0.76 | NUDT1 (0.56) | HRH4HRH3HRH2SMN1; SMN2RAB9A | |
| SCHEMBL3819188 | 0.76 | SMN1; SMN2 (0.51) | HRH4HRH3HRH2SMN1; SMN2RAB9A | |
| SCHEMBL7514947 | 0.76 | HRH4 (0.76) | HRH4SMN1; SMN2PIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101438288-A | Regulation of phosphoryl transferase activity of glutamine synthetase | CSIR CORP (ZA) | 2009-05-20 | — | — | CN | disclosed |
| EP-2008210-A1 | MODULATION OF PHOSPHORYL TRANSFERASE ACTIVITY OF GLUTAMINE SYNTHETASE | CSIR (ZA) | 2008-12-31 | — | — | EP | disclosed |
| WO-2007105023-A1 | MODULATION OF PHOSPHORYL TRANSFERASE ACTIVITY OF GLUTAMINE SYNTHETASE | CSIR (ZA) | 2007-09-20 | — | — | WO | disclosed |
| WO-2007105023-A1 | MODULATION OF PHOSPHORYL TRANSFERASE ACTIVITY OF GLUTAMINE SYNTHETASE | CSIR (ZA) | 2007-09-20 | — | — | WO | disclosed |