Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 2/20 | 0.55 |
| ▸ | HTR2A | P28223 | 1/20 | 0.55 |
| ▸ | CYP19A1 | P11511 | 6/20 | 0.45 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.42 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8251123 | 1.00 | HRH1 (0.55) | HRH1HTR2ACYP19A1TBXA2RSCN5A | |
| SCHEMBL22028771 | 0.98 | HRH1 (0.57) | HRH1HTR2ACYP19A1TBXA2RSCN5A | |
| SCHEMBL2862310 | 0.92 | HRH1 (0.65) | HRH1HTR2ACYP19A1SCN5ASLC6A3 | |
| Hydrochloric Acid SCHEMBL7389223 | 0.90 | HRH1 (0.63) | HRH1HTR2ACYP19A1SCN5ASLC6A3 | |
| SCHEMBL4618800 | 0.83 | HRH1 (0.62) | HRH1HTR2ACYP19A1TAAR1 | |
| SCHEMBL5089222 | 0.81 | HRH1 (0.83) | HRH1HTR2ACYP19A1TAAR1 | |
| SCHEMBL2849801 | 0.81 | HRH1 (0.83) | HRH1HTR2ACYP19A1TAAR1 | |
| SCHEMBL2836377 | 0.81 | HRH1 (0.83) | HRH1HTR2ACYP19A1TAAR1 | |
| SCHEMBL11328616 | 0.81 | HRH1 (0.83) | HRH1HTR2ACYP19A1TAAR1 | |
| SCHEMBL1204774 | 0.81 | HRH1 (0.83) | HRH1HTR2ACYP19A1TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7320993-B1 | Aryl-substituted pyridylalkane, alkene, and alkine carboxamides useful as cytostatic useful as cytostatic and immuosuppressive agents | ASTELLAS DEUTSCHLAND GMBH (DE) | 2008-01-22 | — | — | US | disclosed |
| EP-1042291-B1 | ARYL-SUBSTITUTED PYRIDYLALKANE, ALKENE, AND ALKINE CARBOXAMIDES USEFUL AS CYTOSTATIC AND IMMUNOSUPPRESSIVE AGENTS | KLINGE CO CHEM PHARM FAB (DE) | 2005-07-13 | — | — | EP | disclosed |
| EP-1042291-A1 | ARYL-SUBSTITUTED PYRIDYLALKANE, ALKENE, AND ALKINE CARBOXAMIDES USEFUL AS CYTOSTATIC AND IMMUNOSUPPRESSIVE AGENTS | Klinge Pharma GmbH (DE) | 2000-10-11 | — | — | EP | disclosed |
| WO-1999031064-A1 | ARYL-SUBSTITUTED PYRIDYLALKANE, ALKENE, AND ALKINE CARBOXAMIDES USEFUL AS CYTOSTATIC AND IMMUNOSUPPRESSIVE AGENTS | KLINGE PHARMA GMBH (DE) | 1999-06-24 | — | — | WO | disclosed |