Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 10/20 | 0.60 |
| ▸ | LATS1 | O95835 | 1/20 | 0.46 |
| ▸ | PGR | P06401 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | NCF1 | P14598 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3650311 | 0.81 | NR3C1 (0.71) | NR3C1PGRPOLBMEN1KMT2A | |
| SCHEMBL4817558 | 0.78 | NR3C1 (0.66) | NR3C1PGRPOLBMEN1KMT2A | |
| SCHEMBL6105646 | 0.77 | NR3C1 (0.77) | NR3C1PGRPOLBMEN1KMT2A | |
| SCHEMBL4824848 | 0.77 | NR3C1 (0.86) | NR3C1PGR | |
| SCHEMBL3650510 | 0.76 | NR3C1 (1.00) | NR3C1PGR | |
| SCHEMBL16303304 | 0.75 | NR3C1 (0.49) | NR3C1POLBMEN1KMT2ACYP2C19 | |
| SCHEMBL3651593 | 0.74 | NR3C1 (1.00) | NR3C1PGR | |
| SCHEMBL5173892 | 0.73 | NR3C1 (0.53) | NR3C1PGRPOLBMEN1KMT2A | |
| SCHEMBL4822532 | 0.72 | NR3C1 (0.61) | NR3C1PGRPOLBMEN1KMT2A | |
| SCHEMBL6169279 | 0.72 | NR3C1 (0.61) | NR3C1PGRPOLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2008509191-A | — | — | 2008-03-27 | — | — | JP | claimed |
| EP-1776119-A1 | TETRAHYDRO-NAPHTHALENE DERIVATIVES AS GLUCOCORTICOID RECEPTOR MODULATORS | GLAXO GROUP LIMITED (GB) | 2007-04-25 | — | — | EP | claimed |
| WO-2006015870-A1 | TETRAHYDRO-NAPHTHALENE DERIVATIVES AS GLUCOCORTICOID RECEPTOR MODULATORS | GLAXO GROUP LIMITED (GB) | 2006-02-16 | — | — | WO | claimed |