Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 3/20 | 0.62 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | DRD2 | P14416 | 1/20 | 0.57 |
| ▸ | DRD3 | P35462 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | ACHE | P22303 | 4/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5099761 | 0.90 | ALDH1A1 (0.61) | HDAC1HDAC7TDP1L3MBTL1DRD2 | |
| SCHEMBL17267479 | 0.85 | HDAC7 (0.64) | HDAC1HDAC7TDP1L3MBTL1DRD2 | |
| SCHEMBL17267477 | 0.85 | HDAC7 (0.64) | HDAC1HDAC7TDP1L3MBTL1DRD2 | |
| SCHEMBL17267566 | 0.85 | HDAC7 (0.64) | HDAC1HDAC7TDP1L3MBTL1DRD2 | |
| SCHEMBL17267530 | 0.84 | HDAC1 (0.59) | HDAC1HDAC7TDP1L3MBTL1DRD2 | |
| SCHEMBL8862728 | 0.84 | TDP1 (0.75) | HDAC1HDAC7TDP1L3MBTL1ACHE | |
| SCHEMBL2604742 | 0.84 | TDP1 (0.75) | HDAC1HDAC7TDP1L3MBTL1ACHE | |
| SCHEMBL8863154 | 0.84 | TDP1 (0.75) | HDAC1HDAC7TDP1L3MBTL1ACHE | |
| SCHEMBL6777483 | 0.84 | TDP1 (0.75) | HDAC1HDAC7TDP1L3MBTL1ACHE | |
| SCHEMBL8862878 | 0.84 | TDP1 (0.75) | HDAC1HDAC7TDP1L3MBTL1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7320993-B1 | Aryl-substituted pyridylalkane, alkene, and alkine carboxamides useful as cytostatic useful as cytostatic and immuosuppressive agents | ASTELLAS DEUTSCHLAND GMBH (DE) | 2008-01-22 | — | — | US | disclosed |
| EP-1042291-B1 | ARYL-SUBSTITUTED PYRIDYLALKANE, ALKENE, AND ALKINE CARBOXAMIDES USEFUL AS CYTOSTATIC AND IMMUNOSUPPRESSIVE AGENTS | KLINGE CO CHEM PHARM FAB (DE) | 2005-07-13 | — | — | EP | disclosed |
| EP-1042291-A1 | ARYL-SUBSTITUTED PYRIDYLALKANE, ALKENE, AND ALKINE CARBOXAMIDES USEFUL AS CYTOSTATIC AND IMMUNOSUPPRESSIVE AGENTS | Klinge Pharma GmbH (DE) | 2000-10-11 | — | — | EP | disclosed |
| WO-1999031064-A1 | ARYL-SUBSTITUTED PYRIDYLALKANE, ALKENE, AND ALKINE CARBOXAMIDES USEFUL AS CYTOSTATIC AND IMMUNOSUPPRESSIVE AGENTS | KLINGE PHARMA GMBH (DE) | 1999-06-24 | — | — | WO | disclosed |