Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 1.00 |
| ▸ | HPGD | P15428 | 2/20 | 0.59 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | TLR4 | O00206 | 1/20 | 0.49 |
| ▸ | TLR2 | O60603 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13883090 | 0.88 | ALDH1A1 (0.77) | ALDH1A1SMN1; SMN2KDM4EHPGDPARP10 | |
| SCHEMBL2991930 | 0.85 | ALDH1A1 (0.73) | ALDH1A1SMN1; SMN2KDM4EHPGDPARP10 | |
| SCHEMBL30777705 | 0.84 | SMN1; SMN2 (0.72) | ALDH1A1SMN1; SMN2KDM4EHPGDPARP10 | |
| SCHEMBL1299578 | 0.84 | SMN1; SMN2 (0.72) | ALDH1A1SMN1; SMN2KDM4EHPGDPARP10 | |
| SCHEMBL13268086 | 0.83 | ALDH1A1 (0.70) | ALDH1A1SMN1; SMN2KDM4EHPGDPARP10 | |
| SCHEMBL12948045 | 0.83 | ALDH1A1 (0.70) | ALDH1A1SMN1; SMN2KDM4EHPGDPARP10 | |
| SCHEMBL510249 | 0.83 | ALDH1A1 (0.70) | ALDH1A1SMN1; SMN2KDM4EHPGDPARP10 | |
| SCHEMBL14008497 | 0.82 | ALDH1A1 (0.67) | ALDH1A1SMN1; SMN2KDM4EHPGDPARP10 | |
| SCHEMBL13268124 | 0.82 | ALDH1A1 (0.67) | ALDH1A1SMN1; SMN2KDM4EHPGDPARP10 | |
| SCHEMBL29417058 | 0.81 | ALDH1A1 (0.68) | ALDH1A1SMN1; SMN2KDM4EHPGDPARP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 64 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021127328-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |
| EP-3323816-B1 | NOVEL PYRAZOLE DERIVATIVE | GREEN TECHNOLOGY CO LTD (JP) | 2019-07-03 | — | — | EP | disclosed |
| EP-3323816-A1 | NOVEL PYRAZOLE DERIVATIVE | Green Tech Co., Ltd. (JP) | 2018-05-23 | — | — | EP | disclosed |
| EP-2698368-B1 | NOVEL PYRAZOLE DERIVATIVE | GREEN TECHNOLOGY CO LTD (JP) | 2018-02-14 | — | — | EP | disclosed |
| US-9884832-B2 | Inhibitors targeting drug-resistant influenza A | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2018-02-06 | — | — | US | disclosed |
| CN-103717588-B | Pyrazole derivatives | 绿色科技株式会社 | 2016-08-03 | — | — | CN | disclosed |
| US-9399635-B2 | Pyrazole derivative | GREEN TECH CO., LTD. (JP) | 2016-07-26 | — | — | US | disclosed |
| US-20150191439-A1 | INHIBITORS TARGETING DRUG-RESISTANT INFLUENZA A | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-07-09 | — | — | US | disclosed |
| US-8841327-B2 | Heterocycles substituted pyridine derivatives and antifungal agent containing thereof | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2014-09-23 | — | — | US | disclosed |
| US-8841327-B2 | Heterocycles substituted pyridine derivatives and antifungal agent containing thereof | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2014-09-23 | — | — | US | disclosed |
| EP-1504013-A4 | HYDROXYPHOSPHONATES AND PHOSPHONOPHOSPHATES AS APOLIPOPROTEIN E MODULATORS | ILEX PRODUCTS INC (US) | 2006-05-03 | — | — | EP | disclosed |
| EP-1504013-A2 | HYDROXYPHOSPHONATES AND PHOSPHONOPHOSPHATES AS APOLIPOPROTEIN E MODULATORS | Ilex Products, Inc. (US) | 2005-02-09 | — | — | EP | disclosed |
| EP-0951471-B1 | CYCLOALKYL INHIBITORS OF PROTEIN FARNESYLTRANSFERASE | WARNER LAMBERT CO (US) | 2004-03-17 | — | — | EP | disclosed |
| WO-2003094852-A2 | HYDROXYPHOSPHONATES AND PHOSPHONOPHOSPHATES AS APOLIPOPROTEIN E MODULATORS | ILEX PRODUCTS, INC. (US) | 2003-11-20 | — | — | WO | disclosed |
| US-6300501-B1 | Histidine-(N-benzyl glycinamide) inhibitors of protein farnesyl transferase | WARNER-LAMBERT COMPANY | 2001-10-09 | — | — | US | disclosed |
| US-6281194-B1 | E.G., (S)-(1-((4-BENZYLOXY-BENZYL)-(((1-PHENYL-CYCLOBUTYLMETHYL)-CAR BAMOYL)-METHYL)-CARBAMOYL)-2-(1H-IMIDAZOL-4-YL)-ETHYL)-CARBAMI C ACID BENZYL ESTER | WARNER-LAMBERT COMPANY | 2001-08-28 | — | — | US | disclosed |
| EP-0951471-A1 | CYCLOALKYL INHIBITORS OF PROTEIN FARNESYLTRANSFERASE | WARNER-LAMBERT COMPANY (US) | 1999-10-27 | — | — | EP | disclosed |
| EP-0938494-A1 | INHIBITORS OF PROTEIN FARNESYL TRANSFERASE | WARNER-LAMBERT COMPANY (US) | 1999-09-01 | — | — | EP | disclosed |
| WO-1998027109-A1 | CYCLOALKYL INHIBITORS OF PROTEIN FARNESYLTRANSFERASE | WARNER-LAMBERT COMPANY (US) | 1998-06-25 | — | — | WO | disclosed |
| WO-1997044350-A1 | INHIBITORS OF PROTEIN FARNESYL TRANSFERASE | WARNER-LAMBERT COMPANY (US) | 1997-11-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150191439-A1 | INHIBITORS TARGETING DRUG-RESISTANT INFLUENZA A | HAVCR2, HDLBP, HSP90B1 | ALDH1A1 3831/4885SMN1; SMN2 4878/4885KDM4E 4563/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.