Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 15/20 | 0.83 |
| ▸ | MMP13 | P45452 | 5/20 | 0.68 |
| ▸ | MMP14 | P50281 | 3/20 | 0.68 |
| ▸ | MMP12 | P39900 | 2/20 | 0.68 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.68 |
| ▸ | MMP7 | P09237 | 1/20 | 0.68 |
| ▸ | MMP9 | P14780 | 4/20 | 0.66 |
| ▸ | MMP8 | P22894 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | CLK1 | P49759 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4694515 | 1.00 | MMP2 (0.83) | MMP2MMP13MMP14MMP12ADAMTS4 | |
| SCHEMBL3619369 | 0.94 | MMP2 (0.81) | MMP2MMP13MMP14MMP12ADAMTS4 | |
| SCHEMBL4696678 | 0.91 | MMP2 (1.00) | MMP2MMP13MMP14MMP12ADAMTS4 | |
| SCHEMBL3619909 | 0.91 | MMP2 (1.00) | MMP2MMP13MMP14MMP12ADAMTS4 | |
| SCHEMBL3616183 | 0.90 | MMP2 (0.76) | MMP2MMP13MMP14MMP12ADAMTS4 | |
| SCHEMBL5789599 | 0.90 | MMP2 (0.81) | MMP2MMP13MMP14MMP12ADAMTS4 | |
| SCHEMBL3604331 | 0.90 | MMP2 (0.81) | MMP2MMP13MMP14MMP12ADAMTS4 | |
| SCHEMBL3619226 | 0.90 | MMP2 (0.81) | MMP2MMP13MMP14MMP12ADAMTS4 | |
| SCHEMBL3603710 | 0.90 | MMP2 (0.81) | MMP2MMP13MMP14MMP12ADAMTS4 | |
| SCHEMBL27593737 | 0.90 | MMP2 (0.81) | MMP2MMP13MMP14MMP12ADAMTS4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7420001-B2 | Biaryl sulfonamides and methods for using same | WYETH (US) | 2008-09-02 | — | — | US | disclosed |