Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 14/20 | 0.38 |
| ▸ | DRD3 | P35462 | 8/20 | 0.38 |
| ▸ | DRD4 | P21917 | 6/20 | 0.38 |
| ▸ | HTR1A | P08908 | 8/20 | 0.35 |
| ▸ | HTR2A | P28223 | 7/20 | 0.35 |
| ▸ | HTR2C | P28335 | 4/20 | 0.33 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5138386 | 0.98 | DRD2 (0.39) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL4950739 | 0.89 | DRD2 (0.44) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL4949917 | 0.87 | DRD2 (0.44) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL4952106 | 0.87 | DRD2 (0.45) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL4949751 | 0.87 | DRD2 (0.42) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL4946000 | 0.86 | DRD2 (0.45) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL5088776 | 0.85 | DRD2 (0.35) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL4947399 | 0.85 | DRD2 (0.46) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL4953433 | 0.85 | DRD2 (0.42) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL4952079 | 0.85 | DRD2 (0.43) | DRD2DRD3HTR1AHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2008526700-A | — | — | 2008-07-24 | — | — | JP | claimed |
| EP-1761524-A1 | PHENYL DIAZEPANE CARBOXAMIDES AND ANNELATED PHENYL PIPERAZINE CARBOXAMIDES CONTAINING OXYGEN AND USED AS DOPAMINE D3 ANTAGONISTS | SCHWARZ PHARMA AG (DE) | 2007-03-14 | — | — | EP | claimed |
| WO-2006072430-A1 | PHENYL DIAZEPANE CARBOXAMIDES AND ANNELATED PHENYL PIPERAZINE CARBOXAMIDES CONTAINING OXYGEN AND USED AS DOPAMINE D3 ANTAGONISTS | SCHWARZ PHARMA AG (DE) | 2006-07-13 | — | — | WO | claimed |