Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 9/20 | 0.58 |
| ▸ | AURKB | Q96GD4 | 9/20 | 0.58 |
| ▸ | ACVR1 | Q04771 | 4/20 | 0.53 |
| ▸ | JAK2 | O60674 | 5/20 | 0.53 |
| ▸ | JAK3 | P52333 | 4/20 | 0.53 |
| ▸ | PLK4 | O00444 | 1/20 | 0.46 |
| ▸ | CIT | O14578 | 1/20 | 0.46 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.46 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | FLT1 | P17948 | 1/20 | 0.46 |
| ▸ | FECH | P22830 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4629859 | 0.91 | JAK2 (0.56) | AURKAAURKBACVR1JAK2JAK3 | |
| SCHEMBL5094850 | 0.88 | JAK2 (0.54) | AURKAAURKBACVR1JAK2JAK3 | |
| SCHEMBL5090937 | 0.87 | ACVR1 (0.57) | AURKAAURKBACVR1JAK2JAK3 | |
| SCHEMBL5103295 | 0.85 | ACVR1 (0.54) | AURKAAURKBACVR1JAK2JAK3 | |
| SCHEMBL5103276 | 0.84 | JAK2 (0.54) | AURKAAURKBACVR1JAK2JAK3 | |
| SCHEMBL4629751 | 0.82 | ACVR1 (0.49) | AURKAAURKBACVR1JAK2JAK3 | |
| SCHEMBL5094669 | 0.82 | ACVR1 (0.57) | ACVR1JAK2JAK3PLK4ABL1 | |
| SCHEMBL4629323 | 0.82 | JAK2 (0.57) | AURKAAURKBACVR1JAK2JAK3 | |
| SCHEMBL5103285 | 0.82 | ABL1 (0.54) | AURKAAURKBACVR1JAK2JAK3 | |
| SCHEMBL4629187 | 0.81 | ACVR1 (0.62) | AURKAAURKBACVR1JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080242667-A1 | Pyrimidinyl-Pyrazole Inhibitors of Aurora Kinases | SMITHKLINE BEECHAM CORPORATION | 2008-10-02 | — | — | US | claimed |
| US-20080242667-A1 | Pyrimidinyl-Pyrazole Inhibitors of Aurora Kinases | SMITHKLINE BEECHAM CORPORATION | 2008-10-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080242667-A1 | Pyrimidinyl-Pyrazole Inhibitors of Aurora Kinases | AURKA, AURKC, PLK1 | AURKA 1/4885AURKB 4/4885ACVR1 1609/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.