Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR1 | Q04771 | 14/20 | 0.46 |
| ▸ | CDC7 | O00311 | 1/20 | 0.43 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.43 |
| ▸ | AXL | P30530 | 1/20 | 0.42 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.42 |
| ▸ | MERTK | Q12866 | 1/20 | 0.42 |
| ▸ | CDK4 | P11802 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | BCR | P11274 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5103291 | 0.87 | PIK3CA (0.49) | ACVR1CDC7CDK19CDK4CDK2 | |
| SCHEMBL5090937 | 0.84 | ACVR1 (0.57) | ACVR1 | |
| SCHEMBL5097325 | 0.84 | FLT3 (0.55) | ACVR1CDK2SRCSYK | |
| SCHEMBL4629334 | 0.84 | ABL1 (0.48) | ACVR1AXLTYRO3MERTKABL1 | |
| SCHEMBL5094669 | 0.83 | ACVR1 (0.57) | ACVR1ABL1BCRSRCSYK | |
| SCHEMBL5103305 | 0.82 | ABL1 (0.59) | ACVR1ABL1BCR | |
| SCHEMBL5103647 | 0.76 | ACVR1 (0.53) | ACVR1ABL1BCRSRCSYK | |
| SCHEMBL5097014 | 0.76 | FLT3 (0.49) | ACVR1CDK2 | |
| SCHEMBL4629212 | 0.74 | ACVR1 (0.50) | ACVR1ABL1BCR | |
| SCHEMBL5103672 | 0.73 | CDK2 (0.52) | ACVR1CDK4CDK2SRCSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080242667-A1 | Pyrimidinyl-Pyrazole Inhibitors of Aurora Kinases | SMITHKLINE BEECHAM CORPORATION | 2008-10-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080242667-A1 | Pyrimidinyl-Pyrazole Inhibitors of Aurora Kinases | AURKA, AURKC, PLK1 | ACVR1 1609/4885CDC7 50/4885CDK19 20/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.