Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 5/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.49 |
| ▸ | PLK1 | P53350 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 3/20 | 0.46 |
| ▸ | BCR | P11274 | 3/20 | 0.46 |
| ▸ | PRKCA | P17252 | 3/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 4/20 | 0.44 |
| ▸ | CDK4 | P11802 | 2/20 | 0.44 |
| ▸ | GSK3B | P49841 | 2/20 | 0.44 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.44 |
| ▸ | ACVR1 | Q04771 | 3/20 | 0.44 |
| ▸ | CDC7 | O00311 | 1/20 | 0.42 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.42 |
| ▸ | CDK9 | P50750 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5097233 | 0.87 | ACVR1 (0.46) | PIK3CAPIK3CGABL1BCRSRC | |
| SCHEMBL5103672 | 0.85 | CDK2 (0.52) | PLK1SRCCDK2CDK4GSK3B | |
| SCHEMBL5103295 | 0.85 | ACVR1 (0.54) | PIK3CAPIK3CBPIK3CGPLK1ABL1 | |
| SCHEMBL5090878 | 0.84 | JAK2 (0.54) | ABL1BCRSRCCDK2CDK4 | |
| SCHEMBL5090950 | 0.83 | ABL1 (0.57) | PLK1ABL1BCRPRKCAACVR1 | |
| SCHEMBL4629334 | 0.82 | ABL1 (0.48) | ABL1BCRACVR1 | |
| SCHEMBL5096854 | 0.80 | MEN1 (0.42) | PIK3CAPIK3CBPIK3CGABL1EGFR | |
| SCHEMBL5090865 | 0.78 | JAK2 (0.48) | PLK1EGFRCDK2CDK4GSK3B | |
| SCHEMBL5103237 | 0.78 | JAK2 (0.50) | PIK3CAPIK3CBPIK3CGPLK1ABL1 | |
| SCHEMBL5097244 | 0.74 | JAK2 (0.56) | PIK3CAPIK3CBPIK3CGPLK1ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080242667-A1 | Pyrimidinyl-Pyrazole Inhibitors of Aurora Kinases | SMITHKLINE BEECHAM CORPORATION | 2008-10-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080242667-A1 | Pyrimidinyl-Pyrazole Inhibitors of Aurora Kinases | AURKA, AURKC, PLK1 | PIK3CA 48/4885PIK3CB 144/4885PIK3CG 235/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.