Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.61 |
| ▸ | LRRK2 | Q5S007 | 6/20 | 0.61 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.57 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.54 |
| ▸ | RELA | Q04206 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3054173 | 0.78 | ADORA2A (0.74) | ADORA2AADORA1MEN1KMT2A | |
| SCHEMBL21753710 | 0.76 | LRRK2 (1.00) | LRRK2MEN1KMT2ATP53NPC1 | |
| SCHEMBL3060609 | 0.75 | ADORA2A (0.71) | ADORA2AADORA1MEN1KMT2A | |
| SCHEMBL21753695 | 0.75 | LRRK2 (1.00) | MAPTLRRK2MEN1KMT2ANPC1 | |
| SCHEMBL6687323 | 0.73 | MAPT (0.81) | MAPTMEN1GAAKMT2AMAPK1 | |
| SCHEMBL5563496 | 0.73 | ADORA2A (1.00) | MAPTLRRK2ADORA2AADORA1MEN1 | |
| SCHEMBL3049478 | 0.72 | LRRK2 (0.53) | MAPTLRRK2ADORA2AADORA1MEN1 | |
| SCHEMBL30792785 | 0.72 | LMNA (0.46) | MAPTMEN1GAAKMT2AMAPK1 | |
| SCHEMBL27084288 | 0.72 | LMNA (0.46) | MAPTMEN1GAAKMT2AMAPK1 | |
| SCHEMBL30961687 | 0.72 | MAPT (0.59) | MAPTLRRK2ADORA2AADORA1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7317007-B2 | Benzothiazole derivatives with activity as adenosine receptor ligands | HOFFMANN-LA ROCHE INC. (US) | 2008-01-08 | — | — | US | disclosed |