Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 10/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.41 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4138763 | 0.91 | CASR (0.63) | CASRHDAC1HDAC8HDAC6MEN1 | |
| SCHEMBL4143702 | 0.88 | CASR (0.70) | CASRHDAC1HDAC8HDAC6MEN1 | |
| SCHEMBL4147482 | 0.82 | CASR (0.69) | CASRHDAC1HDAC8HDAC6NR1I2 | |
| SCHEMBL4140148 | 0.80 | CASR (0.49) | CASRHDAC1HDAC8HDAC6LMNA | |
| SCHEMBL4153000 | 0.78 | CASR (0.66) | CASRHDAC1HDAC8HDAC6MEN1 | |
| SCHEMBL4151289 | 0.75 | CASR (0.82) | CASRNR1I2 | |
| SCHEMBL27730770 | 0.74 | CASR (0.59) | CASRMEN1KMT2ALMNATSHR | |
| SCHEMBL4149042 | 0.74 | ALDH1A1 (0.56) | CASRMEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL13851597 | 0.74 | CASR (0.58) | CASRMEN1KMT2ATSHRNR1I2 | |
| SCHEMBL4145053 | 0.73 | CASR (0.57) | CASRMEN1KMT2ALMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951244-A2 | CALCILYTIC COMPOUNDS | SmithKline Beecham Corporation (US) | 2008-08-06 | — | — | EP | disclosed |
| WO-2007062370-A2 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-05-31 | — | — | WO | disclosed |