Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNB2 | O95067 | 10/20 | 1.00 |
| ▸ | CDK1 | P06493 | 10/20 | 1.00 |
| ▸ | CCNB1 | P14635 | 10/20 | 1.00 |
| ▸ | CCNB3 | Q8WWL7 | 10/20 | 1.00 |
| ▸ | CDK4 | P11802 | 4/20 | 1.00 |
| ▸ | CCNA2 | P20248 | 4/20 | 1.00 |
| ▸ | CCND1 | P24385 | 4/20 | 1.00 |
| ▸ | CDK2 | P24941 | 4/20 | 1.00 |
| ▸ | MAPK3 | P27361 | 4/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 4/20 | 1.00 |
| ▸ | KDR | P35968 | 4/20 | 1.00 |
| ▸ | GSK3A | P49840 | 4/20 | 1.00 |
| ▸ | GSK3B | P49841 | 4/20 | 1.00 |
| ▸ | CCNA1 | P78396 | 4/20 | 1.00 |
| ▸ | FGFR2 | P21802 | 3/20 | 1.00 |
| ▸ | CSNK1A1 | P48729 | 3/20 | 1.00 |
| ▸ | CSNK1D | P48730 | 3/20 | 1.00 |
| ▸ | CSNK1E | P49674 | 3/20 | 1.00 |
| ▸ | CSNK1G2 | P78368 | 3/20 | 1.00 |
| ▸ | CSNK1G1 | Q9HCP0 | 3/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25122463 | 0.92 | CDK1 (0.85) | CCNB2CDK1CCNB1CCNB3CDK4 | |
| SCHEMBL5726034 | 0.90 | CDK1 (0.81) | CCNB2CDK1CCNB1CCNB3CDK4 | |
| SCHEMBL5726035 | 0.90 | CDK1 (0.81) | CCNB2CDK1CCNB1CCNB3CDK4 | |
| SCHEMBL25123040 | 0.90 | CDK1 (0.81) | CCNB2CDK1CCNB1CCNB3CDK4 | |
| SCHEMBL25122462 | 0.89 | CDK1 (0.80) | CCNB2CDK1CCNB1CCNB3CDK4 | |
| SCHEMBL5726293 | 0.88 | CCNB2 (0.79) | CCNB2CDK1CCNB1CCNB3CDK4 | |
| SCHEMBL5726491 | 0.88 | CDK1 (1.00) | CCNB2CDK1CCNB1CCNB3CDK4 | |
| SCHEMBL5727085 | 0.88 | CCNB2 (0.78) | CCNB2CDK1CCNB1CCNB3CDK4 | |
| SCHEMBL5964864 | 0.88 | CDK1 (0.78) | CCNB2CDK1CCNB1CCNB3CDK4 | |
| SCHEMBL5964678 | 0.86 | CCNB2 (0.75) | CCNB2CDK1CCNB1CCNB3CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7317031-B2 | Substituted triazole diamine derivatives as kinase inhibitors | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2008-01-08 | — | — | US | disclosed |
| US-7317031-B2 | Substituted triazole diamine derivatives as kinase inhibitors | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2008-01-08 | — | — | US | disclosed |
| CN-100357278-C | Substituted triazole diamine derivatives as kinase inhibitors | ORTHO MCNEIL PHARM INC (US) | 2007-12-26 | — | — | CN | disclosed |
| EP-1712550-A2 | Substituted triazole diamine derivatives as kinase inhibitors | Ortho-McNeil Pharmaceutical, Inc. (US) | 2006-10-18 | — | — | EP | disclosed |
| EP-1355889-B1 | SUBSTITUTED TRIAZOLE DIAMINE DERIVATIVES AS KINASE INHIBITORS | ORTHO MCNEIL PHARM INC (US) | 2006-06-07 | — | — | EP | disclosed |
| US-20050182116-A1 | Substituted triazole diamine derivatives as kinase inhibitors | LIN RONGHUI (US) | 2005-08-18 | — | — | US | disclosed |
| US-6924302-B2 | Substituted triazole diamine derivatives as kinase inhibitors | ORTHO MCNEIL PHARMACEUTICAL, INC. (US) | 2005-08-02 | — | — | US | disclosed |
| CN-1575284-A | Substituted triazole diamine derivatives as kinase inhibitors | ORTHO MCNEIL PHARM INC (US) | 2005-02-02 | — | — | CN | disclosed |
| US-20040077699-A1 | Substituted triazole diamine derivatives as kinase inhibitors | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2004-04-22 | — | — | US | disclosed |
| EP-1355889-A1 | SUBSTITUTED TRIAZOLE DIAMINE DERIVATIVES AS KINASE INHIBITORS | Ortho-McNeil Pharmaceutical, Inc. (US) | 2003-10-29 | — | — | EP | disclosed |
| WO-2002057240-A1 | SUBSTITUTED TRIAZOLE DIAMINE DERIVATIVES AS KINASE INHIBITORS | ORTHO MC NEIL PHARMACEUTICAL, INC. (US) | 2002-07-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050182116-A1 | Substituted triazole diamine derivatives as kinase inhibitors | MAP2K2, PRKDC, MAP2K3 | CCNB2 2020/4885CDK1 387/4885CCNB1 2548/4885 |
| US-20040077699-A1 | Substituted triazole diamine derivatives as kinase inhibitors | MAP2K2, PRKDC, MAP2K3 | CCNB2 2020/4885CDK1 387/4885CCNB1 2548/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.