Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Betamethasone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 8/20 | 0.92 |
| ▸ | HIF1A | Q16665 | 9/20 | 0.92 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.92 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.92 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.92 |
| ▸ | PGR | P06401 | 3/20 | 0.92 |
| ▸ | TSHR | P16473 | 2/20 | 0.92 |
| ▸ | AR | P10275 | 2/20 | 0.92 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.92 |
| ▸ | MEN1 | O00255 | 1/20 | 0.92 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.92 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.92 |
| ▸ | APEX1 | P27695 | 1/20 | 0.92 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.92 |
| ▸ | IKBKB | O14920 | 1/20 | 0.92 |
| ▸ | CHUK | O15111 | 1/20 | 0.92 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.92 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.92 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.92 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.92 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dexamethasone SCHEMBL43108 | 1.00 | HIF1A (0.92) | HIF1ANR3C1CYP3A4HSD17B10NFKB1 | |
| Dexamethasone SCHEMBL122397 | 1.00 | HIF1A (0.92) | HIF1ANR3C1CYP3A4HSD17B10NFKB1 | |
| Betamethasone SCHEMBL515750 | 1.00 | HIF1A (0.92) | HIF1ANR3C1CYP3A4HSD17B10NFKB1 | |
| Betamethasone SCHEMBL7521 | 1.00 | HIF1A (0.92) | HIF1ANR3C1CYP3A4HSD17B10NFKB1 | |
| Betamethasone SCHEMBL28843099 | 0.99 | HIF1A (0.90) | HIF1ANR3C1CYP3A4HSD17B10NFKB1 | |
| Betamethasone SCHEMBL4188771 | 0.99 | HIF1A (0.90) | HIF1ANR3C1CYP3A4HSD17B10NFKB1 | |
| Betamethasone SCHEMBL8077644 | 0.98 | HIF1A (0.89) | HIF1ANR3C1CYP3A4HSD17B10NFKB1 | |
| Betamethasone SCHEMBL28161851 | 0.98 | HIF1A (0.89) | HIF1ANR3C1CYP3A4HSD17B10NFKB1 | |
| Dexamethasone SCHEMBL29137991 | 0.97 | HIF1A (0.98) | HIF1ANR3C1CYP3A4HSD17B10NFKB1 | |
| Betamethasone SCHEMBL120210 | 0.96 | NR3C1 (0.84) | HIF1ANR3C1CYP3A4HSD17B10NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 304 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024125322-A1 | DIPYRIDAMOLE FOR PREVENTING AND TREATING ALLERGIC AND/OR INFLAMMATORY DISEASES AND PREPARATION THEREOF | 智泽童康(广州)生物科技有限公司 | 2024-06-20 | — | — | WO | claimed |
| CN-117849228-A | Biomarker for screening early sexual precocity and application thereof | 裕菁科技(上海)有限公司 | 2024-04-09 | — | — | CN | claimed |
| CN-116999412-A | Sustained-release microsphere preparation containing betamethasone medicine and preparation method thereof | 四川迈可隆生物科技有限公司 | 2023-11-07 | — | — | CN | claimed |
| CN-116265017-A | Pharmaceutical composition comprising benvimod and corticosteroid | 上海泽德曼医药科技有限公司 | 2023-06-20 | — | — | CN | claimed |
| CN-113057943-B | Betamethasone dipropionate nano freeze-dried powder injection and preparation method thereof | 东南大学 | 2022-04-26 | — | — | CN | claimed |
| CN-110082462-B | Chromatography-mass spectrometry detection method for glucocorticoid and sex hormone in cosmetics | 宁波检验检疫科学技术研究院 | 2021-11-19 | — | — | CN | claimed |
| CN-113057943-A | Betamethasone dipropionate nano freeze-dried powder injection and preparation method thereof | 东南大学 | 2021-07-02 | — | — | CN | claimed |
| CN-110693819-B | Pharmaceutical composition for preventing and treating acarid dermatitis and preparation method thereof | 吉林大学 | 2020-10-27 | — | — | CN | claimed |
| CN-107664671-B | Method for detecting residual medicine of animal-derived food | 广东省药品检验所（广东省药品质量研究所、广东省口岸药品检验所） | 2020-08-28 | — | — | CN | claimed |
| CN-111132982-A | Compositions and methods for modulating short-chain dehydrogenase activity | 卡斯西部储备大学 | 2020-05-08 | — | — | CN | claimed |
| WO-2009117120-A1 | PURIFICATION OF AIR SENSITIVE STEROIDS | SICOR INC. (US) | 2009-09-24 | — | — | WO | claimed |
| WO-2009024964-A2 | COMPOSITION AND METHOD FOR THE TREATMENT OF OTITIS EXTERNA | PRIMOR NITSAN (IL) | 2009-02-26 | — | — | WO | claimed |
| EP-1863493-A1 | CORTICOSTEROID CONTAINING FORMULATION FOR TREATING PSORIASIS, ECZEMA, ULCER AND BURNS. | El Masri, Mohamed Zakaria Ahmed (EG) | 2007-12-12 | — | — | EP | claimed |
| WO-2006092151-A1 | TOPICAL CORTICOSTEROID CONTAINING FORMULATION FOR TREATMENT OF PSORIASIS, ECZEMA, ULCER AND BURNS | EL MASRI MOHAMED ZAKARIA AHMED (EG) | 2006-09-08 | — | — | WO | claimed |
| US-6890544-B2 | Gel composition for the topical treatment of poison ivy and other forms of contact dermatitis | MCCADDEN MICHAEL E (US) | 2005-05-10 | — | — | US | claimed |
| US-20030232086-A1 | Gel composition for the topical treatment of rashes, dermatoses and lesions | MCCADDEN MICHAEL E (US) | 2003-12-18 | — | — | US | claimed |
| US-6656928-B1 | Composition for the topical treatment of rashes, dermatoses and lesions | MCCADDEN MICHAEL E (US) | 2003-12-02 | — | — | US | claimed |
| US-20030077304-A1 | Gel composition for the topical treatment of poison ivy and other forms of contact dermatitis | MCCADDEN MICHAEL E (US) | 2003-04-24 | — | — | US | claimed |
| US-6479058-B1 | Composition for the topical treatment of poison ivy and other forms of contact dermatitis | MCCADDEN MICHAEL E (US) | 2002-11-12 | — | — | US | claimed |
| US-4244942-A | Creamy preparation containing steroid and process for the preparation thereof | TOKO YAKUHIN KOGYO KABUSHIKI KAISHA (JP) | 1981-01-13 | — | — | US | claimed |