Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.70 |
| ▸ | RXRA | P19793 | 2/20 | 0.45 |
| ▸ | RXRB | P28702 | 2/20 | 0.45 |
| ▸ | RXRG | P48443 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5090617 | 0.83 | NOTUM (0.59) | NOTUMRXRARXRBRXRGNPC1 | |
| SCHEMBL11616981 | 0.82 | NOTUM (0.47) | NOTUMRXRARXRBRXRGNPC1 | |
| SCHEMBL12188072 | 0.82 | NOTUM (0.47) | NOTUMRXRARXRBRXRGNPC1 | |
| SCHEMBL9830387 | 0.82 | NOTUM (1.00) | NOTUMRXRARXRBRXRGKDM4E | |
| SCHEMBL18567080 | 0.81 | NOTUM (1.00) | NOTUMRXRARXRBRXRGNPC1 | |
| SCHEMBL11617459 | 0.78 | NOTUM (0.44) | NOTUMRXRARXRBRXRGNPC1 | |
| SCHEMBL22042140 | 0.78 | NOTUM (0.59) | NOTUMRXRARXRBRXRGHDAC1 | |
| SCHEMBL11618526 | 0.76 | ALOX5 (0.42) | NOTUMRXRARXRBRXRGNPC1 | |
| SCHEMBL26424617 | 0.76 | TSHR (0.47) | NOTUMRXRARXRBRXRGNPC1 | |
| SCHEMBL7894636 | 0.76 | NOTUM (0.60) | NOTUMRXRARXRBRXRGNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100475792-C | Novel gamma-secretase inhibitors | MERCK SHARP & DOHME (GB) | 2009-04-08 | — | — | CN | disclosed |
| US-7452899-B2 | Gamma-secretase inhibitors | MERCK SHARP & DOHME LIMITED (GB) | 2008-11-18 | — | — | US | disclosed |
| EP-1658272-B1 | NOVEL GAMMA-SECRETASE INHIBITORS | MERCK SHARP & DOHME (GB) | 2007-07-25 | — | — | EP | disclosed |
| CN-1832927-A | Novel gamma-secretase inhibitors | MERCK SHARP & DOHME (GB) | 2006-09-13 | — | — | CN | disclosed |
| US-20060189666-A1 | Novel gamma-secretase inhibitors | MERCK SHARP & DOHME LTD. (GB) | 2006-08-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060189666-A1 | Novel gamma-secretase inhibitors | BACE1, BACE2, APP | NOTUM 554/4885RXRA 4154/4885RXRB 3298/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.