Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 8/20 | 0.73 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.36 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1803753 | 0.86 | P2RX7 (0.84) | P2RX7L3MBTL1EPHX2ROCK2NPC1 | |
| SCHEMBL3838828 | 0.85 | P2RX7 (0.80) | P2RX7L3MBTL1EPHX2ROCK2NPC1 | |
| SCHEMBL1803472 | 0.85 | P2RX7 (1.00) | P2RX7L3MBTL1EPHX2ROCK2NPC1 | |
| Hydrochloric Acid SCHEMBL3836586 | 0.84 | P2RX7 (0.98) | P2RX7L3MBTL1EPHX2ROCK2NPC1 | |
| SCHEMBL1802611 | 0.84 | P2RX7 (0.84) | P2RX7L3MBTL1EPHX2ROCK2NPC1 | |
| SCHEMBL1801630 | 0.83 | P2RX7 (0.76) | P2RX7L3MBTL1EPHX2ROCK2NPC1 | |
| SCHEMBL1809424 | 0.83 | P2RX7 (0.73) | P2RX7L3MBTL1EPHX2ROCK2NPC1 | |
| SCHEMBL5807023 | 0.83 | P2RX7 (0.67) | P2RX7L3MBTL1EPHX2ROCK2NPC1 | |
| SCHEMBL5746004 | 0.83 | P2RX7 (0.67) | P2RX7L3MBTL1EPHX2ROCK2NPC1 | |
| SCHEMBL3841066 | 0.82 | P2RX7 (0.71) | P2RX7L3MBTL1EPHX2ROCK2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7408065-B2 | P2X7 receptor antagonists and their use | ASTRAZENECA AB (SE) | 2008-08-05 | — | — | US | claimed |