Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 18/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 18/20 | 0.49 |
| ▸ | DRD2 | P14416 | 13/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4774162 | 0.91 | DRD3 (0.54) | DRD3KCNH2DRD2ALDH1A1TSHR | |
| SCHEMBL5098397 | 0.87 | DRD3 (0.51) | DRD3KCNH2DRD2 | |
| SCHEMBL5098480 | 0.85 | DRD3 (0.51) | DRD3KCNH2DRD2 | |
| SCHEMBL5111112 | 0.83 | DRD3 (0.49) | DRD3KCNH2DRD2 | |
| SCHEMBL4763714 | 0.83 | KDM4E (0.59) | DRD3KCNH2DRD2ALDH1A1KDM4E | |
| SCHEMBL5099718 | 0.82 | ALDH1A1 (0.58) | DRD3KCNH2DRD2ALDH1A1KDM4E | |
| SCHEMBL5101732 | 0.82 | ALDH1A1 (0.58) | DRD3KCNH2DRD2ALDH1A1KDM4E | |
| SCHEMBL4380463 | 0.81 | DRD3 (0.55) | DRD3KCNH2DRD2ALDH1A1TSHR | |
| SCHEMBL5112125 | 0.79 | DRD3 (0.59) | DRD3KCNH2DRD2 | |
| SCHEMBL4763567 | 0.79 | DRD3 (0.53) | DRD3KCNH2DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7429579-B2 | Tetrahydrobenzazepine derivatives useful as modulators of dopamine D3 receptors (antipsychotic agents) | SMITHKLINE BEECHAM, PLC (GB) | 2008-09-30 | — | — | US | disclosed |