Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 14/20 | 1.00 |
| ▸ | MAPK9 | P45984 | 13/20 | 1.00 |
| ▸ | MAPK10 | P53779 | 10/20 | 1.00 |
| ▸ | PIM1 | P11309 | 2/20 | 0.63 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.63 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.53 |
| ▸ | RET | P07949 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 3/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.48 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.47 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.47 |
| ▸ | JUN | P05412 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.45 |
| ▸ | IKBKB | O14920 | 1/20 | 0.45 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.45 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.45 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8191666 | 1.00 | MAPK8 (1.00) | MAPK8MAPK9MAPK10PIM1PIM2 | |
| SCHEMBL7888011 | 0.82 | MAPK8 (1.00) | MAPK8MAPK9MAPK10IRAK4CDK2 | |
| SCHEMBL183898 | 0.82 | MAPK8 (1.00) | MAPK8MAPK9MAPK10IRAK4CDK2 | |
| SCHEMBL1974294 | 0.78 | PIM1 (1.00) | MAPK8MAPK9MAPK10PIM1PIM2 | |
| SCHEMBL1974296 | 0.78 | PIM1 (1.00) | MAPK8MAPK9MAPK10PIM1PIM2 | |
| SCHEMBL30438261 | 0.74 | RET (0.64) | MAPK8MAPK9MAPK10PIM1PIM2 | |
| SCHEMBL16885494 | 0.71 | MAPK1 (0.72) | MAPK8MAPK9MAPK10CDK2MAPK1 | |
| SCHEMBL413669 | 0.70 | MAPK8 (0.54) | MAPK8MAPK9MAPK10IRAK4CDK2 | |
| SCHEMBL12075528 | 0.70 | KDM4E (0.54) | MAPK8MAPK9MAPK10PIM1PIM2 | |
| SCHEMBL22228838 | 0.70 | MAPK8 (0.67) | MAPK8MAPK9MAPK10IRAK4CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8399462-B2 | 4-[4-(4-benzyloxy-indol-1-yl)-pyrimidin-2-ylamino]-cyclohexanol; autoimmune, inflammatory, metabolic, neurological diseases as well as cancer and pain | ROCHE PALO ALTO LLC (US) | 2013-03-19 | — | — | US | claimed |
| US-20080146565-A1 | JNK modulators | ROCHE PALO ALTO LLC | 2008-06-19 | — | — | US | claimed |
| US-8399462-B2 | 4-[4-(4-benzyloxy-indol-1-yl)-pyrimidin-2-ylamino]-cyclohexanol; autoimmune, inflammatory, metabolic, neurological diseases as well as cancer and pain | ROCHE PALO ALTO LLC (US) | 2013-03-19 | — | — | US | disclosed |
| US-20080146565-A1 | JNK modulators | ROCHE PALO ALTO LLC | 2008-06-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080146565-A1 | JNK modulators | MAPKAPK2, MAPKAPK3, MAP3K10 | MAPK8 40/4885MAPK9 43/4885MAPK10 31/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.