Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.51 |
| ▸ | BRAF | P15056 | 7/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.50 |
| ▸ | RAF1 | P04049 | 3/20 | 0.48 |
| ▸ | ARAF | P10398 | 3/20 | 0.48 |
| ▸ | ABL1 | P00519 | 3/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5139333 | 0.92 | KDR (0.49) | KDRBRAFFGFR1RAF1ARAF | |
| SCHEMBL5105268 | 0.90 | KDR (0.52) | KDRBRAFFGFR1RAF1ARAF | |
| SCHEMBL5106674 | 0.86 | KDR (0.51) | KDRBRAFFGFR1ABL1GPR119 | |
| SCHEMBL5118843 | 0.86 | HTR2A (0.45) | KDRBRAFFGFR1RAF1ABL1 | |
| SCHEMBL5113096 | 0.83 | FLT4 (0.51) | KDRBRAFFGFR1ABL1 | |
| SCHEMBL5104150 | 0.82 | KDR (0.42) | KDRBRAFRAF1ARAFABL1 | |
| SCHEMBL5111764 | 0.82 | RAF1 (0.43) | KDRBRAFRAF1ABL1 | |
| SCHEMBL5119586 | 0.81 | SRC (0.56) | KDRBRAFFGFR1RAF1ABL1 | |
| SCHEMBL5107344 | 0.81 | BRAF (0.52) | KDRBRAFRAF1ARAFMAPK14 | |
| SCHEMBL5118545 | 0.81 | CTSS (0.43) | KDRBRAFABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8609656-B2 | Heteroarylphenylurea derivative | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2013-12-17 | — | — | US | disclosed |
| US-20080119466-A1 | Heteroarylphenylurea Derivative | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2008-05-22 | — | — | US | disclosed |
| US-20080119466-A1 | Heteroarylphenylurea Derivative | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2008-05-22 | — | — | US | disclosed |
| US-20080119466-A1 | Heteroarylphenylurea Derivative | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2008-05-22 | — | — | US | disclosed |
| EP-1724258-A1 | HETEROARYLPHENYLUREA DERIVATIVE | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2006-11-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080119466-A1 | Heteroarylphenylurea Derivative | CHRM1, CBR3, CHRM2 | KDR 2440/4885BRAF 1735/4885FGFR1 982/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.