Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BAX | Q07812 | 2/20 | 0.67 |
| ▸ | MAPT | P10636 | 3/20 | 0.66 |
| ▸ | TP53 | P04637 | 1/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.66 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.66 |
| ▸ | MEN1 | O00255 | 2/20 | 0.63 |
| ▸ | RAD52 | P43351 | 2/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
| ▸ | DNM1 | Q05193 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.50 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5087737 | 1.00 | BAX (0.67) | BAXMAPTTP53CYP3A4ALOX15 | |
| SCHEMBL5025392 | 1.00 | BAX (0.67) | BAXMAPTTP53CYP3A4ALOX15 | |
| SCHEMBL5024544 | 0.94 | MEN1 (0.73) | BAXMAPTTP53CYP3A4ALOX15 | |
| SCHEMBL5026850 | 0.94 | MEN1 (0.73) | BAXMAPTTP53CYP3A4ALOX15 | |
| SCHEMBL5024534 | 0.94 | MEN1 (0.73) | BAXMAPTTP53CYP3A4ALOX15 | |
| SCHEMBL6819686 | 0.89 | BAX (0.82) | BAXMAPTTP53CYP3A4ALOX15 | |
| SCHEMBL30102077 | 0.87 | BAX (0.61) | BAXMAPTTP53CYP3A4ALOX15 | |
| SCHEMBL24811552 | 0.86 | BAX (0.66) | BAXMAPTTP53CYP3A4ALOX15 | |
| SCHEMBL5022531 | 0.86 | BAX (0.50) | BAXMAPTTP53CYP3A4ALOX15 | |
| Hydrochloric Acid SCHEMBL30102320 | 0.85 | MAPT (0.67) | BAXMAPTTP53CYP3A4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1237887-B1 | 9-(PIPERAZINYLALKYL)CARBAZOLES AS BAX-MODULATORS | SERONO LAB (CH) | 2008-06-04 | — | — | EP | claimed |