Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.73 |
| ▸ | RAD52 | P43351 | 2/20 | 0.73 |
| ▸ | BAX | Q07812 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 5/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.60 |
| ▸ | TP53 | P04637 | 2/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5024534 | 1.00 | MEN1 (0.73) | MEN1KMT2ARAD52BAXMAPT | |
| SCHEMBL5024544 | 1.00 | MEN1 (0.73) | MEN1KMT2ARAD52BAXMAPT | |
| SCHEMBL5110159 | 0.94 | BAX (0.67) | MEN1KMT2ARAD52BAXMAPT | |
| SCHEMBL5025392 | 0.94 | BAX (0.67) | MEN1KMT2ARAD52BAXMAPT | |
| SCHEMBL5087737 | 0.94 | BAX (0.67) | MEN1KMT2ARAD52BAXMAPT | |
| SCHEMBL6815606 | 0.91 | MEN1 (0.88) | MEN1KMT2ARAD52BAXMAPT | |
| SCHEMBL5026936 | 0.89 | MEN1 (0.72) | MEN1KMT2ARAD52MAPTMAPK1 | |
| SCHEMBL1305296 | 0.85 | MEN1 (0.78) | MEN1KMT2ARAD52BAXMAPT | |
| SCHEMBL608201 | 0.85 | MEN1 (0.64) | MEN1KMT2ARAD52BAXMAPT | |
| SCHEMBL606958 | 0.85 | MEN1 (0.64) | MEN1KMT2ARAD52BAXMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1237887-B1 | 9-(PIPERAZINYLALKYL)CARBAZOLES AS BAX-MODULATORS | SERONO LAB (CH) | 2008-06-04 | — | — | EP | claimed |